Bilosomes as Nano Platform for Oral Delivery and In Vitro Drug Release Activity of Hesperetin -7-Rhamnoglucoside

Continuing on improvements in nanotechnology, bilosomes can be newfound as a useful nanoplatform for oral drug delivery now. This platform considered some crucial concerns which are low solubility of the medication, stability, and permeability of the gastrointestinal tract. In view of the fact that Hesperetin -7-rhamnoglucoside (Hesperidin) has great pharmacological effects, yet is only orally available due to problems of its poor water solubility and poor adsorption on the gastrointestinal tract, this study considers the synthesis and assessment of bilosomes. We successfully created hesperidin (Hesperetin -7-rhamnoglucoside) loaded in bile salts stabilized vesicles using a thin-film hydration approach that included bile salts to improve vesicle stability and drug encapsulation efficiency. The size, zeta potential, polydispersity index (PDI), entrapment efficiency (EE), and Fourier Transform Infrared Spectroscopy analysis of the bilosomal vesicles were all measured. To determine the release profile of hesperidin from the bilosomal system, in vitro drug release studies were performed under sink conditions mimicking the gastrointestinal environment. Consequently, formulation (F7) is found to possess an EE of 76.43%, a particle size of 218 nm, a PDI of 0.25, a zeta potential of -23.43 mV, and an in vitro drug release of 97.26%. The formulation F7 was found to have the best stability, encapsulation efficiency, and the highest sustained release of the drug when the in vitro drug release profile and particle properties are considered.. KEYWORDS :Hesperidin, Bilosomes, Thin-film hydration, Entrapment efficiency, Zeta potential.