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Translating and Formalizing the MIRAGE Guidelines to a Prototype MIRAGE Ontology and DCAT3 Extension Vocabulary for Glycomics Data Management
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The Minimum Information Required for A Glycomics Experiment (MIRAGE) guidelines haveestablished comprehensive reporting standards for glycomics research, yet their implementationin semantic web technologies remains limited. We present the first comprehensive semanticformalization of MIRAGE guidelines through an integrated RDF ontology framework comprising the MIRAGE Ontology and MIRAGE-DCAT3 vocabulary. The MIRAGE Ontologymodels glycan structures, biological specimens, analytical instruments, and experimental processes with formal OWL semantics and SHACL validation constraints. The complementaryMIRAGE-DCAT3 vocabulary extends W3C DCAT3 with glycomics-specific metadata propertiesfor dataset cataloging and discovery. Our implementation addresses critical challenges inglycomics data interoperability through comprehensive mappings to established ontologiesincluding GlycoRDF, PSI-MS, and DCTERMS. This semantic framework enables automatedquality assessment, federated data querying, and enhanced reproducibility in glycomics research, supporting broader adoption of FAIR principles in the glycobiology community. Theframework demonstrates comprehensive coverage of MIRAGE reporting requirements acrossmultiple analytical platforms including mass spectrometry, liquid chromatography, capillaryelectrophoresis, NMR spectroscopy, and lectin microarray analysis
Title: Translating and Formalizing the MIRAGE Guidelines to a Prototype MIRAGE Ontology and DCAT3 Extension Vocabulary for Glycomics Data Management
Description:
The Minimum Information Required for A Glycomics Experiment (MIRAGE) guidelines haveestablished comprehensive reporting standards for glycomics research, yet their implementationin semantic web technologies remains limited.
We present the first comprehensive semanticformalization of MIRAGE guidelines through an integrated RDF ontology framework comprising the MIRAGE Ontology and MIRAGE-DCAT3 vocabulary.
The MIRAGE Ontologymodels glycan structures, biological specimens, analytical instruments, and experimental processes with formal OWL semantics and SHACL validation constraints.
The complementaryMIRAGE-DCAT3 vocabulary extends W3C DCAT3 with glycomics-specific metadata propertiesfor dataset cataloging and discovery.
Our implementation addresses critical challenges inglycomics data interoperability through comprehensive mappings to established ontologiesincluding GlycoRDF, PSI-MS, and DCTERMS.
This semantic framework enables automatedquality assessment, federated data querying, and enhanced reproducibility in glycomics research, supporting broader adoption of FAIR principles in the glycobiology community.
Theframework demonstrates comprehensive coverage of MIRAGE reporting requirements acrossmultiple analytical platforms including mass spectrometry, liquid chromatography, capillaryelectrophoresis, NMR spectroscopy, and lectin microarray analysis.
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