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Identification of a Third Metalloprotease Toxin Gene in Extraintestinal Isolates of Bacteroides fragilis
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ABSTRACT
To further understand the epidemiology of enterotoxigenic
Bacteroides fragilis
(ETBF), 89 extraintestinal
B. fragilis
strains from Seoul, Korea, were examined for secretion of
B. fragilis
toxin (BFT) by the HT29/C1 biologic assay and for the
B. fragilis
toxin gene (
bft
) by colony blot hybridization and PCR. Complete agreement between the three techniques was found. Overall, 34
B. fragilis
strains (38%) were identified as ETBF. Eleven of the 34 ETBF strains (32%) expressed a new isoform of BFT (Korea-BFT). This new isoform is more related to BFT-2 than to BFT-1. Like BFT-1 and BFT-2, Korea-BFT cleaves E-cadherin, the zonula adherens protein.
American Society for Microbiology
Title: Identification of a Third Metalloprotease Toxin Gene in Extraintestinal Isolates of
Bacteroides fragilis
Description:
ABSTRACT
To further understand the epidemiology of enterotoxigenic
Bacteroides fragilis
(ETBF), 89 extraintestinal
B.
fragilis
strains from Seoul, Korea, were examined for secretion of
B.
fragilis
toxin (BFT) by the HT29/C1 biologic assay and for the
B.
fragilis
toxin gene (
bft
) by colony blot hybridization and PCR.
Complete agreement between the three techniques was found.
Overall, 34
B.
fragilis
strains (38%) were identified as ETBF.
Eleven of the 34 ETBF strains (32%) expressed a new isoform of BFT (Korea-BFT).
This new isoform is more related to BFT-2 than to BFT-1.
Like BFT-1 and BFT-2, Korea-BFT cleaves E-cadherin, the zonula adherens protein.
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