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Ovarian-dedifferentiated endometrioid adenocarcinoma: A rare case report
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ABSTRACT
We reported a case of dedifferentiated ovarian carcinoma in a 51-year-old woman. The microscopic tumor consisted of well-differentiated endometrioid carcinoma and undifferentiated carcinoma. Undifferentiated carcinoma was characterized by high-grade nuclear features, mainly solid growth, vacuolar nuclei, frequent nuclear division, and necrosis. Undifferentiated carcinoma did not express epithelial immune markers; p53 was completely deficient in both components; the expression of MMR proteins was only deficient in low-grade endometrioid carcinoma, while it was preserved in undifferentiated carcinoma; SMARCB1/INI1 was diffused expression in both components; SOX2 was diffusely expressed in undifferentiated carcinoma, but not in well-differentiated components; SMARCA4/BRG1 was inactivated in undifferentiated components. These resulted in a poor prognosis.
Ovid Technologies (Wolters Kluwer Health)
Title: Ovarian-dedifferentiated endometrioid adenocarcinoma: A rare case report
Description:
ABSTRACT
We reported a case of dedifferentiated ovarian carcinoma in a 51-year-old woman.
The microscopic tumor consisted of well-differentiated endometrioid carcinoma and undifferentiated carcinoma.
Undifferentiated carcinoma was characterized by high-grade nuclear features, mainly solid growth, vacuolar nuclei, frequent nuclear division, and necrosis.
Undifferentiated carcinoma did not express epithelial immune markers; p53 was completely deficient in both components; the expression of MMR proteins was only deficient in low-grade endometrioid carcinoma, while it was preserved in undifferentiated carcinoma; SMARCB1/INI1 was diffused expression in both components; SOX2 was diffusely expressed in undifferentiated carcinoma, but not in well-differentiated components; SMARCA4/BRG1 was inactivated in undifferentiated components.
These resulted in a poor prognosis.
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