New Bioactive Coordination Polymers With Sulfosalicylic Acid: Synthesis, Characterization, Cytotoxicity, Antiradical Activity, and Adsorption Properties

ABSTRACTThree new coordination polymers (CPs) formulated—[Cu(5‐SSA)Cu2(MEA)2]·2H2O (1) (where 5‐SSA = 5‐sulfosalicylic acid, MEA = monoethanolamine); [Mn(SSA)4(H2O)2]n (MEA)(H2O) (2); [Na (SSA)]MEA (3)—have been prepared and characterized by various spectroscopic techniques, elemental analysis, and single‐crystal X‐ray diffraction method. In 1, coordination numbers of both copper ions are six with octahedron geometry. Further, this compound has complicated intermolecular H‐bonds in the polymeric structure that incorporate polymeric chains into 3‐D networks. Compound 2 also exhibits a polymeric bimolecular chain structure and features two intramolecular hydrogen bonds, both having the same graph‐set notation of S11(6) in the structure. Further, it is a supramolecular compound (clathrate or host‐guest complex) with inclusion of monoethanolamine (MEA) and water. Similarly, 2‐D polymeric layer structure of compound 3 with strong H‐bonds generated a 3‐D network. All these CPs were explored to study their cytotoxicity, antiradical activity, and adsorption properties. The cytotoxicity results indicate that compound 1 has acute toxicity in the mice, characterized by adverse effects and a significant mortality rate. Further, the average lethal dose (LD50) of the compounds 1–3 is estimated 546, 708, and 750 mg/kg, respectively. In case of antiradical activity, the CPs 2 and 3 have high antioxidant radical forming (ARF) capability. The adsorption of N₂ at low temperatures was evaluated using an Autosorb device and the measured P0 value at 77 K was 101.3 kPa. In addition, the surface area of these compounds were also determined by Brunauer–Emmett–Teller (BET), which affirmed 311.9, 526.69, and 349.8781 m2/g for compounds 1–3, respectively. The nitrogen adsorption data revealed that compounds 1 and 2 contain only mesopores, while compound 3 consists exclusively of micropores. Barrett–Joyner–Halenda (BJH) method was explored to determine mesopore volume with values of 0.171459, 0.808656, and 0.11969 cm3/g for compounds 1–3, respectively.