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Analysis of DEXI/<i>Dexi</i> refines the organization of the mouse 7C and human 15q11→q13 imprinting clusters
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Identification of imprinted genes in the Prader-Willi/Angelman syndrome deletion region is complicated by the presence of large flanking repeats. While inactive copies of DEXI are located within the repeats, we have now localized the active DEXI gene to 15q11→q13 outside the PWS/AS deletion and <i>Dexi</i> to mouse chromosome 16, suggesting complex evolution of this genomic region in both species.
Title: Analysis of DEXI/<i>Dexi</i> refines the organization of the mouse 7C and human 15q11→q13 imprinting clusters
Description:
Identification of imprinted genes in the Prader-Willi/Angelman syndrome deletion region is complicated by the presence of large flanking repeats.
While inactive copies of DEXI are located within the repeats, we have now localized the active DEXI gene to 15q11→q13 outside the PWS/AS deletion and <i>Dexi</i> to mouse chromosome 16, suggesting complex evolution of this genomic region in both species.
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