Screening History and Diagnostic Characteristics of Cervical Adenocarcinoma: a Retrospective Study

Abstract Background: An increasing trend in incidence of cervical adenocarcinoma has been observed in recent years. This research aims to study the screening history and diagnostic characteristics of cervical adenocarcinoma.Methods: Cervical cancer patients hospitalized in the Gynecology Department of the Third Affiliated Hospital of Sun Yat-sen University between 1st Jan 2017 and 31st Mar 2020 were included. Cervical screening history investigation and analysis were carried out by medical record data inquiry and case investigation.Results: (1)The chief complaint of 72.0% of cervical squamous cell carcinoma was vaginal bleeding. 75.6% of adenocarcinoma came in for abnormal vaginal discharge, p<0.001. (2)The HPV infection rate in adenocarcinoma(74.2%) was lower than that in squamous cell carcinoma(92.9%), p<0.001. (3)The participation rate of cervical screening before diagnosis of adenocarcinoma(21.2%) was higher than that of squamous cell carcinoma(2.8%), p＜0.01. (4) The proportion of early-stage in adenocarcinoma (46.3%) was larger than in SCC (28.3%), p<0.01. Conclusion: Compared to cervical squamous cell carcinoma, HPV infection was found to be less closely associated with adenocarcinoma of uterine cervix. The participation rate and frequency of cervical screening of patients with cervical adenocarcinom were more than squamous cell carcinoma. The screening methods at present may not be sensitive enough for precancerous lesion of adenocarcinoma, but regular and multiple screening are still of great significance for early diagnosis of adenocarcinoma of uterine cervix.