Correlation Between Mild Behavioral Impairment and Peripheral Blood Biomarkers in Patients with Mild Cognitive Impairment

Abstract Objective We examined the prevalence of Mild behavioral impairment (MBI) in healthy older adults (HOA) and individuals with mild cognitive impairment (MCI), and the association between MBI and plasma biomarkers of Alzheimer's disease(AD). Methods A total of 241 subjects (136 HOA and 105 MCI) were enrolled in the Yuhua District of Shijiazhuang City in China. The MBI Symptom Checklist (MBI-C) was employed for assessment and diagnosis of MBI (MBI-C ≥ 6.5). Fasting venous blood was collected from 70 patients (32 HOA, 38 MCI), and Aβ40, Aβ42, and P-Tau217 levels were measured using enzyme-linked immunosorbent assay. Results The prevalence of MBI in HOA and MCI groups was 4.4% and 15.3%, respectively (χ2 = 7.262, P = 0.007), especially in terms of decreased motivation, impulse dyscontrol (highest detection rate), and social inappropriateness (P < 0.05). MBI total score was correlated with Aβ42 and P-Tau217 (r=-0.385, P = 0.019; r=-0.330, P = 0.041), but not with Aβ40 or Aβ42/40 ratio. Among the subdomains, impulse dyscontrol submains was correlated with Aβ42 (r=-0.401, P = 0.025). Conclusion Both MCI and HOA demonstrated a higher prevalence of MBI, with change in impulse control behavior being the most common. MBI not only serves as an independent risk factor for cognitive decline but is also associated with AD-related peripheral biomarkers.