Penile Squamous Cell Carcinoma Presenting with Ulceration and Nodal Involvement: 2 Case Reports

INTRODUCTION Penile cancer which presents very rarely but is of high importance because of difficult diagnosis and therapeutic challenges. Neoplasm of the penis is relatively rare in most regions representing 0-2% of cancers worldwide(1). Penile cancer as the GLOBOCAN Cancer Statistics estimated 36,068 (0.2%) new cases of penile cancer and 13,211 (0.1%) penile cancer related deaths worldwide in 2020 (2).Penile cancer is rare, and the oncological details about its occurrence in under 45 are unclear and unidentified. Penile cancer in men under 45 is very rare with an incidence rate of 0.1 to 0.8/100,000 (3). There are different types but most common is squamous cell carcinoma of penis which accounts for about 95% of penile cancer (4). Penile squamous cell carcinoma shows prevalence of 0.1-1 per 100,000 men in high-income countries, but it constitutes up to 10% of malignancies in men in some African, Asian and South American regions (5). About 40% of penile cancers re associated with HPV infection (5). Incidence of penile cancer is less than 1% in Pakistan because of the neonatal circumcision factor. The most common site for lesion is glans or foreskin (in uncircumcised male). The risk factors include HPV infection, poor hygiene, phimosis, absence of neonatal circumcision. Its early diagnosis aids in its treatment, prognosis and quality of life.