Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The magnitude of extended-spectrum beta-lactamase- producing Enterobacteriaceae from clinical samples in Ethiopia: a systematic review and meta-analysis
View through CrossRef
Background. The rapid spread of resistance among extended-spectrum β-lactamase (ESBL)-producing
Enterobacteriaceae
is a serious problem around the world. It results in serious clinical complications in humans and has become a global threat. Therefore, this systematic review and meta-analysis was aimed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia.
Methods. A systematic search was conducted on PubMed, Web of Science, Embase, Google Scholar and the Cochrane Library. All identified observational studies reporting the prevalence of ESBL-producing
Enterobacteriaceae
from clinical samples in Ethiopia were included. Four authors independently extracted data and analysed using R software version 3.6.1 and STATA statistical software version 13. A random-effects model was computed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in Ethiopia.
Results. Of 142 articles reviewed, 14 studies that fulfilled the inclusion criteria were included in the meta-analysis. The pooled prevalence of ESBL-producing
Enterobacteriaceae
in the different clinical specimens in Ethiopia was 49 % (95 % CI: 39, 60).
Klebsiella pneumoniae
was the leading ESBL-producing
Enterobacteriaceae
followed by
Escherichia coli
and
Acinetobacter baumannii
with a prevalence of 74, 67 and 60 %, respectively. ESBL-producing isolates showed a high rate of resistance to cefotaxime, ceftriaxone, ceftazidime, Amoxicillin clavulanic acid (AMC), ampicillin and aztreonam. The better options for the treatment of ESBL-producing
Enterobacteriaceae
are amikacin and Imipenem.
Conclusion. The magnitude of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia is alarmingly high and represents a threat to human health. Hence, a coordinated effort needs to be implemented for the prevention and control of these
Enterobacteriaceae
.
Microbiology Society
Title: The magnitude of extended-spectrum beta-lactamase- producing Enterobacteriaceae from clinical samples in Ethiopia: a systematic review and meta-analysis
Description:
Background.
The rapid spread of resistance among extended-spectrum β-lactamase (ESBL)-producing
Enterobacteriaceae
is a serious problem around the world.
It results in serious clinical complications in humans and has become a global threat.
Therefore, this systematic review and meta-analysis was aimed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia.
Methods.
A systematic search was conducted on PubMed, Web of Science, Embase, Google Scholar and the Cochrane Library.
All identified observational studies reporting the prevalence of ESBL-producing
Enterobacteriaceae
from clinical samples in Ethiopia were included.
Four authors independently extracted data and analysed using R software version 3.
6.
1 and STATA statistical software version 13.
A random-effects model was computed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in Ethiopia.
Results.
Of 142 articles reviewed, 14 studies that fulfilled the inclusion criteria were included in the meta-analysis.
The pooled prevalence of ESBL-producing
Enterobacteriaceae
in the different clinical specimens in Ethiopia was 49 % (95 % CI: 39, 60).
Klebsiella pneumoniae
was the leading ESBL-producing
Enterobacteriaceae
followed by
Escherichia coli
and
Acinetobacter baumannii
with a prevalence of 74, 67 and 60 %, respectively.
ESBL-producing isolates showed a high rate of resistance to cefotaxime, ceftriaxone, ceftazidime, Amoxicillin clavulanic acid (AMC), ampicillin and aztreonam.
The better options for the treatment of ESBL-producing
Enterobacteriaceae
are amikacin and Imipenem.
Conclusion.
The magnitude of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia is alarmingly high and represents a threat to human health.
Hence, a coordinated effort needs to be implemented for the prevention and control of these
Enterobacteriaceae
.
Related Results
High prevalence of fecal carriage of Extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae among food handlers at the University of Gondar, Northwest Ethiopia
High prevalence of fecal carriage of Extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae among food handlers at the University of Gondar, Northwest Ethiopia
BackgroundFecal carriage of extended-spectrum beta-lactamase and Carbapenemase-producing Enterobacteriaceae is a potential risk for the transmission of infection with resistant str...
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical a...
Isolation of extended spectrum beta-lactamase producing Enterobacteriaceae among children with urinary tract infection: A cross sectional study.
Isolation of extended spectrum beta-lactamase producing Enterobacteriaceae among children with urinary tract infection: A cross sectional study.
Abstract
Background: Resistance of Gram-negative bacteria to antibiotics had increased at an alarming pace over the last two decades. Empirical antibiotic treatment of UTI ...
Bacterial profile and extended spectrum beta lactamase screening of urinary tract infection among asymptomatic and symptomatic pregnant women attending antenatal care in ALERT Hospital, Addis Ababa, Ethiopia
Bacterial profile and extended spectrum beta lactamase screening of urinary tract infection among asymptomatic and symptomatic pregnant women attending antenatal care in ALERT Hospital, Addis Ababa, Ethiopia
Introduction: The occurrence of extended spectrum beta lactamase-producing uropathogens, especially in pregnant women can result in life-threatening condition and morbidity for bot...
Colonization with extended-spectrum β-lactamase and carbapenemase-producing Enterobacterales in Ethiopia: A systematic review and meta-analysis
Colonization with extended-spectrum β-lactamase and carbapenemase-producing Enterobacterales in Ethiopia: A systematic review and meta-analysis
Background
The human intestinal tract contains many commensals. However, during an imbalance of the normal microbiota following exposure to antibiotics, extended-spectrum β-lactam...
Magnitude and antimicrobial susceptibility patterns of extended-spectrum β-lactamase producing Enterobacteriaceae recovered from environmental samples at Tikur Anbessa Specialized Hospital, Ethiopia
Magnitude and antimicrobial susceptibility patterns of extended-spectrum β-lactamase producing Enterobacteriaceae recovered from environmental samples at Tikur Anbessa Specialized Hospital, Ethiopia
Abstract
Background
The hospital environment especially the intensive care units (ICUs) contributes to the spread of extended-spectrum β-lactamase (ESBL) producing Enterob...
Prevalence of carbapenemase-producing Enterobacteriaceae from human clinical samples in Ethiopia: a systematic review and meta-analysis
Prevalence of carbapenemase-producing Enterobacteriaceae from human clinical samples in Ethiopia: a systematic review and meta-analysis
Abstract
Introduction
Carbapenemase-producing Enterobacteriaceae are by far the most public health and urgent clinical problems with antibiotic resi...
Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice.
Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice.
Abstract
Intracerebral infection of certain strains of mice with Theiler's virus results in chronic immune-mediated demyelination in spinal cord. We used mouse mutan...