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The magnitude of extended-spectrum beta-lactamase- producing Enterobacteriaceae from clinical samples in Ethiopia: a systematic review and meta-analysis
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Background. The rapid spread of resistance among extended-spectrum β-lactamase (ESBL)-producing
Enterobacteriaceae
is a serious problem around the world. It results in serious clinical complications in humans and has become a global threat. Therefore, this systematic review and meta-analysis was aimed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia.
Methods. A systematic search was conducted on PubMed, Web of Science, Embase, Google Scholar and the Cochrane Library. All identified observational studies reporting the prevalence of ESBL-producing
Enterobacteriaceae
from clinical samples in Ethiopia were included. Four authors independently extracted data and analysed using R software version 3.6.1 and STATA statistical software version 13. A random-effects model was computed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in Ethiopia.
Results. Of 142 articles reviewed, 14 studies that fulfilled the inclusion criteria were included in the meta-analysis. The pooled prevalence of ESBL-producing
Enterobacteriaceae
in the different clinical specimens in Ethiopia was 49 % (95 % CI: 39, 60).
Klebsiella pneumoniae
was the leading ESBL-producing
Enterobacteriaceae
followed by
Escherichia coli
and
Acinetobacter baumannii
with a prevalence of 74, 67 and 60 %, respectively. ESBL-producing isolates showed a high rate of resistance to cefotaxime, ceftriaxone, ceftazidime, Amoxicillin clavulanic acid (AMC), ampicillin and aztreonam. The better options for the treatment of ESBL-producing
Enterobacteriaceae
are amikacin and Imipenem.
Conclusion. The magnitude of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia is alarmingly high and represents a threat to human health. Hence, a coordinated effort needs to be implemented for the prevention and control of these
Enterobacteriaceae
.
Microbiology Society
Title: The magnitude of extended-spectrum beta-lactamase- producing Enterobacteriaceae from clinical samples in Ethiopia: a systematic review and meta-analysis
Description:
Background.
The rapid spread of resistance among extended-spectrum β-lactamase (ESBL)-producing
Enterobacteriaceae
is a serious problem around the world.
It results in serious clinical complications in humans and has become a global threat.
Therefore, this systematic review and meta-analysis was aimed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia.
Methods.
A systematic search was conducted on PubMed, Web of Science, Embase, Google Scholar and the Cochrane Library.
All identified observational studies reporting the prevalence of ESBL-producing
Enterobacteriaceae
from clinical samples in Ethiopia were included.
Four authors independently extracted data and analysed using R software version 3.
6.
1 and STATA statistical software version 13.
A random-effects model was computed to estimate the pooled prevalence of ESBL-producing
Enterobacteriaceae
in Ethiopia.
Results.
Of 142 articles reviewed, 14 studies that fulfilled the inclusion criteria were included in the meta-analysis.
The pooled prevalence of ESBL-producing
Enterobacteriaceae
in the different clinical specimens in Ethiopia was 49 % (95 % CI: 39, 60).
Klebsiella pneumoniae
was the leading ESBL-producing
Enterobacteriaceae
followed by
Escherichia coli
and
Acinetobacter baumannii
with a prevalence of 74, 67 and 60 %, respectively.
ESBL-producing isolates showed a high rate of resistance to cefotaxime, ceftriaxone, ceftazidime, Amoxicillin clavulanic acid (AMC), ampicillin and aztreonam.
The better options for the treatment of ESBL-producing
Enterobacteriaceae
are amikacin and Imipenem.
Conclusion.
The magnitude of ESBL-producing
Enterobacteriaceae
in different clinical samples in Ethiopia is alarmingly high and represents a threat to human health.
Hence, a coordinated effort needs to be implemented for the prevention and control of these
Enterobacteriaceae
.
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