Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
NEW ANTIRHEUMATIC SUBSTANCE BASED ON PHENOLIC GLYCOSIDE STRUCTURE METHYL (4-О-Β-GLUCOPYRANOSYLOXY)-BENZOIC ACID
View through CrossRef
Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-β-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-β-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-β-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-β-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib.
Penerbit UTM Press
Title: NEW ANTIRHEUMATIC SUBSTANCE BASED ON PHENOLIC GLYCOSIDE STRUCTURE METHYL (4-О-Β-GLUCOPYRANOSYLOXY)-BENZOIC ACID
Description:
Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually.
The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID).
Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications.
Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-β-glucopyranosyloxy)-benzoic acid.
In this study we evaluated the methyl (4-О-β-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect.
According to the results, methyl (4-О-β-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group.
Therefore, methyl (4-О-β-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib.
.
Related Results
Influence of microbial bioinoculants on the accumulation of new phytocompounds in Oroxylum indicum (L.) Benth. ex Kurz
Influence of microbial bioinoculants on the accumulation of new phytocompounds in Oroxylum indicum (L.) Benth. ex Kurz
The seedlings of Oroxylum indicum were inoculated with plant growth promoting microbes (PGPMs) mainly, Glomus mosseae, Trichoderma harzianum and Pseudomonas putida both alone and c...
The Role of Personality and Stress in the Development of Substance Use Disorder among Substance Use Disorder Patients in Kaduna State, Nigeria
The Role of Personality and Stress in the Development of Substance Use Disorder among Substance Use Disorder Patients in Kaduna State, Nigeria
This study investigated the role of personality and stress in the development of substance use disorder among substance use disorder patients in Kaduna State. A cross sectional des...
A case-control study of the association of toxoplasmosis with antirheumatic therapy in rheumatoid arthritis
A case-control study of the association of toxoplasmosis with antirheumatic therapy in rheumatoid arthritis
Background & Objective: Toxoplasmosis is a globally prevalent opportunistic zoonotic infection. Rheumatoid arthritis (RA) is an autoimmune disease which is manifested as joint ...
British Food Journal Volume 46 Issue 11 1944
British Food Journal Volume 46 Issue 11 1944
1. From the information given to the Committee by members of the trade the following conclusions were drawn : (i) Four main types of product are sold under a name commonly includin...
Synthesis and Anticancer Activity of Metformin‐Phenolic Acid Conjugates
Synthesis and Anticancer Activity of Metformin‐Phenolic Acid Conjugates
ABSTRACT
The leading cause of death worldwide is cancer. Several studies suggest phenolic acids and metformin as potential cancer treatment o...
Substance Abuse Education for Nurse Anesthetists: Differences in Knowledge of Substance Abuse between Student Nurse Anesthetists who have Completed a Substance Abuse Workshop and those who have Not
Substance Abuse Education for Nurse Anesthetists: Differences in Knowledge of Substance Abuse between Student Nurse Anesthetists who have Completed a Substance Abuse Workshop and those who have Not
The purpose of this study was to determine whether student nurse anesthetists who took a substance abuse workshop had more knowledge of substance abuse than those who did not take ...
INVESTIGATION OF NEW NSAIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF KIDNEY AND URINARY TRACT
INVESTIGATION OF NEW NSAIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF KIDNEY AND URINARY TRACT
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the world, primarily due to their high efficiency for the treatment of inflammatory induced pain syndrome. The mai...
Substance use and associated factors among preparatory school students in Kolfe-Keranyo sub-city of Addis Ababa, Ethiopia
Substance use and associated factors among preparatory school students in Kolfe-Keranyo sub-city of Addis Ababa, Ethiopia
Abstract
Background
Substance abuse is a worldwide problem that primarily affects adolescents, resulting in chronic health complications as well as ...