Comparison of Clomiphene Citrate and Letrozole in induction of ovulation among patients with PolyCystic Ovarian syndrome (PCOS) Primary Sub-fertility

Objective: To compare the efficacy of clomiphene and Letrozole in the induction of ovulation in patients with primary ovarian sub-fertility. Methodology:  This was a Randomized control trial study carried out at Dow University Hospital Karachi, Ojha Campus, Karachi after approval of synopsis from February 2016 to January 2017. The required sample size was 164 (82 in the Letrozole group and 82 in the CC group). Non-probability consecutive sampling technique was used. Females of 18-40 years irrespective of weight, years of marriage, and duration of sub-fertility with primary ovarian sub-fertility were included in the study. SPSS was used for data analysis. Results: Total of 164 women were enrolled in the study. 82 women were given Clomiphene Citrate and 82 were treated with Letrozole. The mean age was found to be 28.48±4.12 in the clomiphene citrate group whereas 28.45±3.01 in the Letrozole group. The results showed improved results among the group with Letrozole drug compared to Clomiphene Citrate. Efficacy was positively found with 1st cycle, 2nd cycle & 3rd cycle in 2 (2.4%), 23 (28.05%) & 32 (39.02%) respondents respectively with Clomiphene Citrate. Whereas efficacy was positive with 1st cycle, 2nd cycle & 3rd cycle in 18 (21.9%), 34 (41.4%) & 24 (29.2%) respondents respectively with Letrozole. Conclusion: Letrozole appeared to be the effective drug of choice in ovulation induction among patients who failed to conceive, however, the clomiphene citrate was found to be most effective in women. The dosage of Letrozole is much lower mg with effective pregnancy results compared to Clomiphene Citrate clomiphene citrate.