RESEARCH ON ACUTE TOXICITY AND SEMI-CHRONIC TOXICITY OF MEDICINAL FUNGUS CORDYCEPS TAKAOMONTANA

The article presents the evaluation of acute and semi-chronic toxicity of medicinal fungus Cordyceps takaomontana which extract was developed by Institute of Biotechnology of the Vietnam Academy of Science and Technology. In the course of the experiment under mice that drank water with added Cordyceps takaomontana extract, concentration of which was 975 times less than the concentration used for humans, symptoms of poisoning (signs of acute toxicity) were not revealed. Examining semi-chronic toxicity was taken under rabbits that were fed with Cordyceps takaomontana extract in doses 0.24 and 1.2 g/kg of mass once a day during 30 days. Rabbits’ general condition and mass, functions of blood, liver and kidneys, biochemical and hematological parameters have been studied; their liver and kidneys histology during and after taking Cordyceps takaomontana extract for 15 days was carried out.In the course of the study it has been found that Cordyceps takaomontana extract is absolutely not toxic. The results obtained serve a scientific justification for using fungus Cordyceps takaomontana in food and pharmaceutical production for preparing food and medicinal products.