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Sericin improve diabetic cognitive impairment in rats by inhibiting TXNIP/NLRP3 neuroinflammation through SIRT1
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Aims: The aim of this study was to examine the effects of
sericin on diabetic cognitive impairment (DCI) in rats based on
neuroinflammation. Methods: SD rats were firstly fed with high
sugar and high fat diet for 4 weeks, and then injected with 50 mg/kg
streptozotocin intraperitoneally to establish a diabetic model. The
diabetic rats were randomly divided into 3 groups and treated with
distilled water (n=10), 500 mg/kg (n =10) and 1000 mg/kg (n=20) sericin,
respectively, by gavage once a day for 8 weeks. Before the end of the
trail, 10 rats in the 1000 mg/kg sericin group were injected with 10 μg
EX527 (a SIRT1 inhibitor) into the lateral ventricles once every other
day for 5 times. Results: Treated with sericin significantly
reduced the fasting blood glucose, improved DCI in rats. Sericin
significantly inhibited of neuroinflammation, reduced the expression of
NLRP3, TXNIP proteins and reduced cell apoptosis, while increased the
expression of SIRT1 protein in the hippocampus of diabetic rats. After
inhibiting SIRT1 with EX527, the above effect of sericin on DCI rats was
weakened. Conclusions: These results indicated that sericin may
block DCI progression in rats by inhibiting TXNIP/NLRP3
neuroinflammation and neuronal apoptosis though SIRT1.
Title: Sericin improve diabetic cognitive impairment in rats by inhibiting TXNIP/NLRP3 neuroinflammation through SIRT1
Description:
Aims: The aim of this study was to examine the effects of
sericin on diabetic cognitive impairment (DCI) in rats based on
neuroinflammation.
Methods: SD rats were firstly fed with high
sugar and high fat diet for 4 weeks, and then injected with 50 mg/kg
streptozotocin intraperitoneally to establish a diabetic model.
The
diabetic rats were randomly divided into 3 groups and treated with
distilled water (n=10), 500 mg/kg (n =10) and 1000 mg/kg (n=20) sericin,
respectively, by gavage once a day for 8 weeks.
Before the end of the
trail, 10 rats in the 1000 mg/kg sericin group were injected with 10 μg
EX527 (a SIRT1 inhibitor) into the lateral ventricles once every other
day for 5 times.
Results: Treated with sericin significantly
reduced the fasting blood glucose, improved DCI in rats.
Sericin
significantly inhibited of neuroinflammation, reduced the expression of
NLRP3, TXNIP proteins and reduced cell apoptosis, while increased the
expression of SIRT1 protein in the hippocampus of diabetic rats.
After
inhibiting SIRT1 with EX527, the above effect of sericin on DCI rats was
weakened.
Conclusions: These results indicated that sericin may
block DCI progression in rats by inhibiting TXNIP/NLRP3
neuroinflammation and neuronal apoptosis though SIRT1.
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