A comprehensive review on Calendula officinalis

Calendula officinalis commonly known as pot marigold, has a long history of use in traditional medicine. This review aims to provide a comprehensive overview of Calendula officinalis, encompassing its botanical characteristics, chemical composition, traditional uses, pharmacological activities supported by scientific evidence, clinical trials, toxicity, and potential future applications. The flowering plant Calendula officinalis belongs to the Asteraceae family. In China, India, and Europe, this plant is utilised as a remedy. It is sometimes referred to as "African marigold" and has been the focus of several pharmacological and chemical studies. A thorough search of relevant databases and review was conducted to gather information. It has a long history as a traditional remedy for inflammation, ulcers, skin and digestive problems, nervousness, insomnia and many other ailments. Calendula contains a wide range of constituents, including terpenoids, carotenoids, flavonoids, volatile oils, polysaccharides and coumarins. Several studies have scientifically confirmed the plant’s medicinal properties, including anti-inflammatory, healing, regenerative, antimicrobial, anticancer, antigenotoxic and genotoxic, hepatoprotective, neuroprotective, cardioprotective, gastroprotective, antioxidant, spasmogenic and spasmolytic, antiprotozoal, anthelmintic, acaricidal, antiviral, anti-ageing and immunostimulant effects