Pathogenesis of Type 2 Diabetes

Title: Pathogenesis of Type 2 Diabetes

Description:

AbstractThe sections in this article are:Insulin Secretion in T2DMFasting Insulin ConcentrationGlucose‐Stimulated Insulin SecretionOther Abnormalities in Insulin Secretion in T2DMMechanisms of Impaired Insulin SecretionGlucose ToxicityLipotoxicityOther Mechanisms of Impaired Insulin Secretion in T2DMImpaired Insulin Secretion: Primary Genetic Defect Responsible for Type 2 DiabetesProspective StudiesStudies in First‐Degree RelativesStudies in TwinsSubjects with History of Gestational Diabetes MellitusHypersecretion of Insulin as the Cause of Type 2 Diabetes: A New HypothesisSummary: Insulin Secretion in T2DMInsulin Sensitivity in Type 2 DiabetesSite of Insulin Resistance in Type 2 DiabetesFasting Hyperglycemia: Role of Pancreas, Muscle and LiverPostprandial Hyperglycemia: Lessons from the Oral Glucose Tolerance TestDynamic Interaction Between Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes MellitusCellular Mechanisms of Insulin Resistance in Type 2 DiabetesOverview of Insulin ActionInsulin Receptor/Insulin Receptor Signal Transduction DefectsGlucose TransportGlucose PhosphorylationGlycogen SynthesisGlycolysis/Glucose OxidationMetabolic, Hemodynamic, Endocrine, and Cytokine Abnormalities in Type 2 Diabetes MellitusGlucose ToxicityLipid Oxidation and Insulin ResistanceSkeletal Muscle Capillary Density, Fiber Type and Endothelial TransportBlood FlowAmylin and Calcitonin Gene‐Related PeptideTumor Necrosis Factor‐AlphaAcquired Determinants of Insulin ResistanceSummary of Insulin Resistance in Type 2 Diabetes MellitusGenetic DefectsPathogenesis of Type 2 Diabetes Mellitus: Summary and SynthesisPrimary Defect in Insulin SensitivityPrimary Defect in Insulin Secretion?Combined Defects in Insulin Sensitivity and Insulin SecretionConclusion.