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Alterations of Physostigmine‐Induced Yawning by Chronic Lithium Administration in Rats
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Abstract:The effect of chronic lithium pretreatment on physostigmine‐induced yawning was investigated in male rats. Intraperitoneal administration of physostigmine to rats induced yawning in a biphasic manner. However the maximum response was obtained by 0.2 mg/kg of the drug. Intracerebroventricular administrations of a putative M1and M2muscarinic receptor antagonists, pirenzepine and methoctramine decreased physostigmine‐induced yawning. Intraperitoneal administration of a non‐selective muscarinic receptor antagonist, atropine, also decreased the physostigmine‐induced yawning significantly. Chronic lithium pretreatment (30 days) reduced yawning induced by physostigmine. The inhibitory effect of pirenzepine. methoctramine and atropine on physostigmine‐induced yawning increased in rats pretreated with chronic lithium. These findings indicate that yawning is induced by a central cholinergic mechanism and that chronic pretreatment of lithium may interact with the cholinergic‐induced behaviour.
Title: Alterations of Physostigmine‐Induced Yawning by Chronic Lithium Administration in Rats
Description:
Abstract:The effect of chronic lithium pretreatment on physostigmine‐induced yawning was investigated in male rats.
Intraperitoneal administration of physostigmine to rats induced yawning in a biphasic manner.
However the maximum response was obtained by 0.
2 mg/kg of the drug.
Intracerebroventricular administrations of a putative M1and M2muscarinic receptor antagonists, pirenzepine and methoctramine decreased physostigmine‐induced yawning.
Intraperitoneal administration of a non‐selective muscarinic receptor antagonist, atropine, also decreased the physostigmine‐induced yawning significantly.
Chronic lithium pretreatment (30 days) reduced yawning induced by physostigmine.
The inhibitory effect of pirenzepine.
methoctramine and atropine on physostigmine‐induced yawning increased in rats pretreated with chronic lithium.
These findings indicate that yawning is induced by a central cholinergic mechanism and that chronic pretreatment of lithium may interact with the cholinergic‐induced behaviour.
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