Javascript must be enabled to continue!
Physics Design of Epi-Thermal Neutron Beam for BNCT Based on C-MNSR
View through CrossRef
Boron Neutron Capture Therapy (BNCT) is a kind of the targeted therapy with two element. It can kill the cancer cells while the effect on normal cells is very small, and it is suitable for the treatment of the various stage cancer so it will be the ideal radiotherapy for cancer treatment in the future. And Commercial Miniature Neutron Source Reactor (C-MNSR) was designed and constructed by CIAE, which is used for Neutron Activation Analysis (NAA), Training and teaching. The reactor with thermal power 27kW is an under-moderated reactor with pool-tank type, U-AL alloy with High Enriched Uranium (HEU) as fuel, light water as coolant and moderator, and metal beryllium as reflector. The fission heat produced by the reactor is removed by the natural circulation. Design C-MNSR with a epi-thermal neutron beam for BNCT is studied while the conversion from HEU to LEU (Low Enrichment Uranium) (235U percent≤20%) is carried on. As it has the advantages of MNSR safety, economy, easy operation and its application, and it can improve the epi-thermal neutron flux density and meet the requirements of BNCT.
The fuel cage of C-MNSR with size of φ230×248mm in the reactor core, there are ton rows of 355lattices are concentrically arranged, the central lattice is reserved for central control rod, and four tie rods are uniformly arranged at the eighth row which link the upper and lower grid plates, the rest 350 fuel lattices are for fuel pins or dummies. The diameter of the fuel meat is 4.3mm, the height is 230mm, with Uranium enrichment is 17%; the diameter of the fuel element is 5.5mm, the height is 248mm. The frame design of the epithermal neutron beam is: Fluental material used as neutron moderation layer with its thickness is 50cm and its density is 2.85g/cm3; Cd with thickness of 0.1cm used as thermal neutron absorption layer, Lead with thickness of 10cm used as gamma ray shielding layer. And the neutron collimator parts is a composition of graphite, Cd and polythene with boron. The total length of the beam is 114.5cm, and the distance from the exit of the beam to the core is 130cm. The results show that the epithermal neutron flux density at the exit is 1.58 × 109n·cm-2·s-1 at full power of 27kW. and the fast neutron density at the exit is 5.45 × 107n · cm-2 · s-1 at full power. Fast neutron dose contamination (Df/ φepi) is 2.88 × 10−11Gy · cm2 · n−1 and gamma dose contamination (Dγ/φepi) 2.18× 10−14 Gy·cm2·n−1.
Title: Physics Design of Epi-Thermal Neutron Beam for BNCT Based on C-MNSR
Description:
Boron Neutron Capture Therapy (BNCT) is a kind of the targeted therapy with two element.
It can kill the cancer cells while the effect on normal cells is very small, and it is suitable for the treatment of the various stage cancer so it will be the ideal radiotherapy for cancer treatment in the future.
And Commercial Miniature Neutron Source Reactor (C-MNSR) was designed and constructed by CIAE, which is used for Neutron Activation Analysis (NAA), Training and teaching.
The reactor with thermal power 27kW is an under-moderated reactor with pool-tank type, U-AL alloy with High Enriched Uranium (HEU) as fuel, light water as coolant and moderator, and metal beryllium as reflector.
The fission heat produced by the reactor is removed by the natural circulation.
Design C-MNSR with a epi-thermal neutron beam for BNCT is studied while the conversion from HEU to LEU (Low Enrichment Uranium) (235U percent≤20%) is carried on.
As it has the advantages of MNSR safety, economy, easy operation and its application, and it can improve the epi-thermal neutron flux density and meet the requirements of BNCT.
The fuel cage of C-MNSR with size of φ230×248mm in the reactor core, there are ton rows of 355lattices are concentrically arranged, the central lattice is reserved for central control rod, and four tie rods are uniformly arranged at the eighth row which link the upper and lower grid plates, the rest 350 fuel lattices are for fuel pins or dummies.
The diameter of the fuel meat is 4.
3mm, the height is 230mm, with Uranium enrichment is 17%; the diameter of the fuel element is 5.
5mm, the height is 248mm.
The frame design of the epithermal neutron beam is: Fluental material used as neutron moderation layer with its thickness is 50cm and its density is 2.
85g/cm3; Cd with thickness of 0.
1cm used as thermal neutron absorption layer, Lead with thickness of 10cm used as gamma ray shielding layer.
And the neutron collimator parts is a composition of graphite, Cd and polythene with boron.
The total length of the beam is 114.
5cm, and the distance from the exit of the beam to the core is 130cm.
The results show that the epithermal neutron flux density at the exit is 1.
58 × 109n·cm-2·s-1 at full power of 27kW.
and the fast neutron density at the exit is 5.
45 × 107n · cm-2 · s-1 at full power.
Fast neutron dose contamination (Df/ φepi) is 2.
88 × 10−11Gy · cm2 · n−1 and gamma dose contamination (Dγ/φepi) 2.
18× 10−14 Gy·cm2·n−1.
Related Results
Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax
Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax
Abstract
Background
Boron neutron capture therapy (BNCT) is an alternative treatment modality for patients with glioma. The aim of this study was...
Measurement of Neutron Flux at Thermal Column Using Gold Foil Activation Analysis and TLD Detector: Technical Review
Measurement of Neutron Flux at Thermal Column Using Gold Foil Activation Analysis and TLD Detector: Technical Review
The thermal column at the TRIGA PUSPATI (RTP) research reactor can produce thermal neutron. However, the optimization on the thermal neutron flux produced should be performed to ga...
Comparative study of the effect of neutrons emitted from neutron source
241
Am-Be and curcumin on MCF-7 breast cancer cells in 3D culture medium
Comparative study of the effect of neutrons emitted from neutron source
241
Am-Be and curcumin on MCF-7 breast cancer cells in 3D culture medium
Abstract
Introduction
Cancer is one of the major medical problems threatening human health. Breast cancer ...
Abstract 5051: Assessment of boron delivery peptides with angiopep-2 for boron neutron capture therapy
Abstract 5051: Assessment of boron delivery peptides with angiopep-2 for boron neutron capture therapy
Abstract
Boron neutron capture therapy (BNCT) induces intracellular nuclear reactions that release heavy charged particles to destroy cancer cells during thermal neu...
Study of coded source neutron imaging based on a compact accelerator
Study of coded source neutron imaging based on a compact accelerator
Compact accelerator based neutron source has lower cost and better flexibility than nuclear reactor. Neutron imaging using such a neutron source has attracted more and more attenti...
Optimization of DD-110 Neutron Generator Output for Boron Neutron Capture Therapy Using Monte Carlo Simulation
Optimization of DD-110 Neutron Generator Output for Boron Neutron Capture Therapy Using Monte Carlo Simulation
Boron neutron capture therapy (BNCT) is a specialized cancer treatment that leverages the high absorption cross-section of boron for thermal neutrons. When boron captures neutrons,...
A New Method of Porosity Determination by D-T Neutron Generator and Dual CLYC Detector
A New Method of Porosity Determination by D-T Neutron Generator and Dual CLYC Detector
Porosity is one of the essential parameters in conventional oil and gas reservoir evaluation, as well as plays an important role in the calculation of formation saturation and rese...
Preliminary Design of Unloading Device for MNSR LEU Conversion
Preliminary Design of Unloading Device for MNSR LEU Conversion
In order to solve the problem that the current unloading operation will destroy the sealing performance of Miniature Neutron Source Reactor (MNSR) reactor vessel and the tightness ...

