Search engine for discovering works of Art, research articles, and books related to Art and Culture
ShareThis
Javascript must be enabled to continue!

Physics Design of Epi-Thermal Neutron Beam for BNCT Based on C-MNSR

View through CrossRef
Boron Neutron Capture Therapy (BNCT) is a kind of the targeted therapy with two element. It can kill the cancer cells while the effect on normal cells is very small, and it is suitable for the treatment of the various stage cancer so it will be the ideal radiotherapy for cancer treatment in the future. And Commercial Miniature Neutron Source Reactor (C-MNSR) was designed and constructed by CIAE, which is used for Neutron Activation Analysis (NAA), Training and teaching. The reactor with thermal power 27kW is an under-moderated reactor with pool-tank type, U-AL alloy with High Enriched Uranium (HEU) as fuel, light water as coolant and moderator, and metal beryllium as reflector. The fission heat produced by the reactor is removed by the natural circulation. Design C-MNSR with a epi-thermal neutron beam for BNCT is studied while the conversion from HEU to LEU (Low Enrichment Uranium) (235U percent≤20%) is carried on. As it has the advantages of MNSR safety, economy, easy operation and its application, and it can improve the epi-thermal neutron flux density and meet the requirements of BNCT. The fuel cage of C-MNSR with size of φ230×248mm in the reactor core, there are ton rows of 355lattices are concentrically arranged, the central lattice is reserved for central control rod, and four tie rods are uniformly arranged at the eighth row which link the upper and lower grid plates, the rest 350 fuel lattices are for fuel pins or dummies. The diameter of the fuel meat is 4.3mm, the height is 230mm, with Uranium enrichment is 17%; the diameter of the fuel element is 5.5mm, the height is 248mm. The frame design of the epithermal neutron beam is: Fluental material used as neutron moderation layer with its thickness is 50cm and its density is 2.85g/cm3; Cd with thickness of 0.1cm used as thermal neutron absorption layer, Lead with thickness of 10cm used as gamma ray shielding layer. And the neutron collimator parts is a composition of graphite, Cd and polythene with boron. The total length of the beam is 114.5cm, and the distance from the exit of the beam to the core is 130cm. The results show that the epithermal neutron flux density at the exit is 1.58 × 109n·cm-2·s-1 at full power of 27kW. and the fast neutron density at the exit is 5.45 × 107n · cm-2 · s-1 at full power. Fast neutron dose contamination (Df/ φepi) is 2.88 × 10−11Gy · cm2 · n−1 and gamma dose contamination (Dγ/φepi) 2.18× 10−14 Gy·cm2·n−1.
Title: Physics Design of Epi-Thermal Neutron Beam for BNCT Based on C-MNSR
Description:
Boron Neutron Capture Therapy (BNCT) is a kind of the targeted therapy with two element.
It can kill the cancer cells while the effect on normal cells is very small, and it is suitable for the treatment of the various stage cancer so it will be the ideal radiotherapy for cancer treatment in the future.
And Commercial Miniature Neutron Source Reactor (C-MNSR) was designed and constructed by CIAE, which is used for Neutron Activation Analysis (NAA), Training and teaching.
The reactor with thermal power 27kW is an under-moderated reactor with pool-tank type, U-AL alloy with High Enriched Uranium (HEU) as fuel, light water as coolant and moderator, and metal beryllium as reflector.
The fission heat produced by the reactor is removed by the natural circulation.
Design C-MNSR with a epi-thermal neutron beam for BNCT is studied while the conversion from HEU to LEU (Low Enrichment Uranium) (235U percent≤20%) is carried on.
As it has the advantages of MNSR safety, economy, easy operation and its application, and it can improve the epi-thermal neutron flux density and meet the requirements of BNCT.
The fuel cage of C-MNSR with size of φ230×248mm in the reactor core, there are ton rows of 355lattices are concentrically arranged, the central lattice is reserved for central control rod, and four tie rods are uniformly arranged at the eighth row which link the upper and lower grid plates, the rest 350 fuel lattices are for fuel pins or dummies.
The diameter of the fuel meat is 4.
3mm, the height is 230mm, with Uranium enrichment is 17%; the diameter of the fuel element is 5.
5mm, the height is 248mm.
The frame design of the epithermal neutron beam is: Fluental material used as neutron moderation layer with its thickness is 50cm and its density is 2.
85g/cm3; Cd with thickness of 0.
1cm used as thermal neutron absorption layer, Lead with thickness of 10cm used as gamma ray shielding layer.
And the neutron collimator parts is a composition of graphite, Cd and polythene with boron.
The total length of the beam is 114.
5cm, and the distance from the exit of the beam to the core is 130cm.
The results show that the epithermal neutron flux density at the exit is 1.
58 × 109n·cm-2·s-1 at full power of 27kW.
and the fast neutron density at the exit is 5.
45 × 107n · cm-2 · s-1 at full power.
Fast neutron dose contamination (Df/ φepi) is 2.
88 × 10−11Gy · cm2 · n−1 and gamma dose contamination (Dγ/φepi) 2.
18× 10−14 Gy·cm2·n−1.

Related Results

Study of dose rate in the brain model based on the neutron beam of SUT-MNSR
Study of dose rate in the brain model based on the neutron beam of SUT-MNSR
Boron neutron capture therapy (BNCT) is tumor-cell targeted radiotherapy that has significant superiority over conventional radiotherapies. The most neutron beams used for BNCT are...
Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax
Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax
Abstract Background Boron neutron capture therapy (BNCT) is an alternative treatment modality for patients with glioma. The aim of this study was...
Measurement of Neutron Flux at Thermal Column Using Gold Foil Activation Analysis and TLD Detector: Technical Review
Measurement of Neutron Flux at Thermal Column Using Gold Foil Activation Analysis and TLD Detector: Technical Review
The thermal column at the TRIGA PUSPATI (RTP) research reactor can produce thermal neutron. However, the optimization on the thermal neutron flux produced should be performed to ga...
BNCT Displays Cytotoxic Effect on Malignant Meningioma Via the Induction of DNA Damage
BNCT Displays Cytotoxic Effect on Malignant Meningioma Via the Induction of DNA Damage
Malignant meningiomas are an aggressive cancer with high recurrence and poor prognosis. It is difficult to treat via surgical resection and radiotherapy, especially recurrent menin...
A Method for Determining the Porosity of Pulsed Neutron by Combining Gamma Energy and Time Spectrum
A Method for Determining the Porosity of Pulsed Neutron by Combining Gamma Energy and Time Spectrum
Pulsed-neutron gamma energy spectroscopy and neutron lifetime measurement systems enable the evaluation of the elemental content, saturation. And recent studies have demonstrated t...
Abstract 5051: Assessment of boron delivery peptides with angiopep-2 for boron neutron capture therapy
Abstract 5051: Assessment of boron delivery peptides with angiopep-2 for boron neutron capture therapy
Abstract Boron neutron capture therapy (BNCT) induces intracellular nuclear reactions that release heavy charged particles to destroy cancer cells during thermal neu...
Study of coded source neutron imaging based on a compact accelerator
Study of coded source neutron imaging based on a compact accelerator
Compact accelerator based neutron source has lower cost and better flexibility than nuclear reactor. Neutron imaging using such a neutron source has attracted more and more attenti...

Back to Top