Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Cellular Angiofibroma of the Prostate
View through CrossRef
ABSTRACT
Introduction
Cellular angiofibroma is a rare, benign mesenchymal tumor that affects middle‐aged adults. It most frequently arises in the vulvovaginal or inguinoscrotal region. It is characterized by a slow clinical progression with no known potential for recurrence or metastasis.
Case Presentation
In this case, we report a 78‐year‐old man presenting with obstructive lower urinary tract symptoms. Transrectal ultrasonography revealed a prostate volume of approximately 150 cc. The patient underwent an open retropubic prostatectomy (Hryntschak) to relieve symptoms. Histopathological evaluation revealed a proliferation of bland, spindle‐shaped cells within a collagenous stroma interspersed with dilated, thick‐walled blood vessels. Immunohistochemical analysis showed positivity for smooth muscle actin, desmin, and CD34 and negative staining for S100. Fluorescence in situ hybridization revealed a deletion at chromosome 13q14. These morphological and molecular findings support the diagnosis of cellular angiofibroma.
Conclusion
To our knowledge, this is a rare case of cellular angiofibroma originating in the prostate.
Title: Cellular Angiofibroma of the Prostate
Description:
ABSTRACT
Introduction
Cellular angiofibroma is a rare, benign mesenchymal tumor that affects middle‐aged adults.
It most frequently arises in the vulvovaginal or inguinoscrotal region.
It is characterized by a slow clinical progression with no known potential for recurrence or metastasis.
Case Presentation
In this case, we report a 78‐year‐old man presenting with obstructive lower urinary tract symptoms.
Transrectal ultrasonography revealed a prostate volume of approximately 150 cc.
The patient underwent an open retropubic prostatectomy (Hryntschak) to relieve symptoms.
Histopathological evaluation revealed a proliferation of bland, spindle‐shaped cells within a collagenous stroma interspersed with dilated, thick‐walled blood vessels.
Immunohistochemical analysis showed positivity for smooth muscle actin, desmin, and CD34 and negative staining for S100.
Fluorescence in situ hybridization revealed a deletion at chromosome 13q14.
These morphological and molecular findings support the diagnosis of cellular angiofibroma.
Conclusion
To our knowledge, this is a rare case of cellular angiofibroma originating in the prostate.
Related Results
Extranasopharyngeal Angiofibroma from Hypopharynx: A Rare Case Report
Extranasopharyngeal Angiofibroma from Hypopharynx: A Rare Case Report
Angiofibroma is a histologically benign mesenchymal tumor though it is a potentially locally destructive fibrovascular tumor. Angiofibroma located in the head and neck comprises na...
Abstract 5758: Deletions of olfactomedin 4 gene is associated with progression of prostate cancer
Abstract 5758: Deletions of olfactomedin 4 gene is associated with progression of prostate cancer
Abstract
The human olfactomedin 4 gene (OLFM4) encodes an olfactomedin-related glycoprotein, which our group first cloned and characterized in myeloid cells and mapp...
Study on Early Prostate Cancer Antigen (EPCA) and existent risk factors of prostate cancer, Sudan: A case-control study
Study on Early Prostate Cancer Antigen (EPCA) and existent risk factors of prostate cancer, Sudan: A case-control study
Background: Early prostate cancer antigen (EPCA), a nuclear matrix protein, has recently been recommended as a hopeful biomarker for early prostate carcinogenesis. Objectives: To e...
Abstract 1568: The role of CCL2 CCL17 CCL22-CCR4 axis in prostate cancer metastasis
Abstract 1568: The role of CCL2 CCL17 CCL22-CCR4 axis in prostate cancer metastasis
Abstract
BACKGROUND: Multiple steps and factors are involved in prostate carcinogenesis and tumor progression. The early studies have found that tumor-associated mac...
Atypical extra nasopharyngeal angiofibroma in an unusual location: tonsil posterior pillar (oropharynx)
Atypical extra nasopharyngeal angiofibroma in an unusual location: tonsil posterior pillar (oropharynx)
Introduction. Angiofibroma is a benign, locally aggressive highly vascular tumor that typically affects young adolescent males and has a pathognomonic epicenter of origin in the na...
Analysis of the spatial distribution and clinical features of prostate cancer in transperineal prostate biopsy
Analysis of the spatial distribution and clinical features of prostate cancer in transperineal prostate biopsy
Abstract
Background Recently, most studies on the spatial distribution of the prostate cancer are based on the samples confirmed by transrectal prostate biopsy (TRBx), whic...
Predictive value of prostate calcification for future cancer occurrence: a retrospective long-term follow-up cohort study
Predictive value of prostate calcification for future cancer occurrence: a retrospective long-term follow-up cohort study
Objective: Although prostate calcification is often identified on pelvic CT images, calcification itself is usually not considered clinically significant. A recent histological stu...
Correlation between Prostate-Specific Antigen Levels and Prostate Imaging Reporting and Data System score: A Retrospective Study
Correlation between Prostate-Specific Antigen Levels and Prostate Imaging Reporting and Data System score: A Retrospective Study
Introduction: Prostate cancer is a prevalent and potentially lethal malignancy affecting men worldwide. To enhance early detection and accurate risk stratification, various diagnos...