Diagnostic Value of Hypoxia-Inducible Factor 1 Alpha and Adrenomedullin in Acute Mesenteric Ischemia

Abstract INTRODUCTION This study aims to evaluate the diagnostic significance of adrenomedullin and hypoxia-inducible factor 1 alpha (HIF1-alpha) levels in an animal model of acute mesenteric ischemia. MATERIALS AND METHODS In our study, a total of 21 male New Zealand rabbits were used, and the animals were divided into three groups for the study. Blood samples were taken for adrenomedullin and HIF1-alpha levels at 0, 1, 3, and 6 hours from the control, sham, ischemia groups. RESULTS HIF levels of the ischemia group at the 3rd and 6th hours were statistically significantly higher than those in the sham (p = 0.002, p < 0.001, respectively) and control groups (p = 0.002, p < 0.001, respectively). Adrenomedullin levels of the ischemia group at the 1st, 3rd, and 6th hours were statistically significantly higher than those in the sham (p = 0.004, p < 0.001, p < 0.001, respectively) and control groups (p < 0.001, p < 0.001, p < 0.001 respectively). CONCLUSION HIF1-alpha and adrenomedullin have significant potential in the early diagnosis of acute mesenteric ischemia. In the emergency department setting, consideration of these markers and the patient's symptoms and signs may facilitate the diagnostic process.