Lipid Lowering and Hepatoprotective Activity of Premna Tomentosa Leaf Extract (EPT) against Alcohol Induced Toxicity in Rats

The present  study aims to determine the  hepatoprotective and lipid lowering property  of ethanolic leaf extract  of Premna tomentosa (EPT) in alcohol induced hepatotoxicity. Chronic ethanol consumption is a significant danger factor in deciding liver disorders and other  metabolic conditions through  various mechanisms, including the  regulation of the  lipid metabolism. Medicinal plants are accepted  to be a significant wellspring of new chemical substances with expected  remedial impacts. Premna tomentosa (Verbenaceae) is a popular medicinal plant used extensively for the treatment of various ailments widely used in liver disorders.  In the present  research  study, the  male  albino  Wister rats were  grouped  (I-V) each consisting  of  6 animals. In-vivo administration of 40 %  ethanol (1 ml/100 gm b w/day) for 60  days resulted in  a significant elevation  in  Total  cholesterol, Triglycerides,  LDL, and VLDL levels  whereas  the  levels of  HDL was found to  be decreased  when compared  with  the control rats. Liver tissues disclose central vein and sinusoidal capillary dilation, interface hepatitis, cytoplasmic vacuolization and mononuclear cell infiltration which confirms the  intensity of liver damage due to  chronic alcohol ingestion. Simultaneous EPT supplementation (500mg/kg and 750 mg/kg bw) to alcohol -intoxicated rats, reduced the levels of Total cholesterol, triglycerides, and lipoproteins consequential as analogized with the  unsupplemented alcohol- treated   rats.   Liver of rats  pre-treated with ethanolic  extract   of  Premna  tomentosa (500  mg  and  750  mg)  manifest  reduced   formation  of  interface  hepatitis,  vascular congestion, and fatty degeneration and exhibits more hepatoprotection compared  with the rats pre-treated in Liv 52. The blood parameters   were  amplified by the  histopathological perusal of the  liver. The  lipid  -lowering property  by the  derivatives of cinnamic acid showed anticholesteremic activity. The results confirm the Hepatoprotective and lipid -lowering ability of Premna tomentosa in alcohol-treated rats.