Clinico-Pathological Study on Amlapittaw.s.r to Gastroesophageal Reflux Disease (GERD)and its Comparative Management with Narikela Khanda and Kusmanda Khanda.

Introduction: Amlapittadescribed in Ayurvedaclassics resembles to the clinical features of GERD.Amlapittais more prevalent disease ofAnnavaha Srotasa(gastrointestinal system) described in various classicalAyurvedictexts.Narikela Khandaand Kushmanda Khandaare the formulations mentioned in Bhaisajya Ratnavaliindicated for management of Amlapitta. Aims:To evaluate the effect of NarikelaKhanda and KushmandaKhanda in management of Amlapitta. Materials and methods: A non-randomized, single-armed, open-labeled clinical trial was conducted in 30 patients having classical symptoms ofAmlapitta,administered with 10gm ofNarikela Khanda & 10gmof Kushmanda Khandatwice a day after food for 30 days respectively. The assessment was done based on subjective parameters, i.e., Amlodgara(sourbelching),Daha(heartburn),Gaurava(heaviness),Utklesha(nausea),Avipaka(indigestion) andAruchi(loss of appetite) were taken into consideration. The subjective parameters were analysed by Wilcoxon-W test and p-value. Result-In Group A, 6.67% patients had marked improvement, while 73.33% patients had moderate improvement and 20.00% mildly improved. In Group B, 60.00% patients had moderate improvement and 40% marked improved. In both the Group the result was statistically significant, but improvement was noticed more in Group-B. Conclusion-On comparison between two groups, Kushmanda Khandahave shown more effect than Narikela Khanda.No adverse effects were noticed during clinical trial in both groups