Intratumoral Delivery of Chlorine Dioxide Exploits its ROS-like Properties: A Novel Paradigm for Effective Cancer Therapy

Abstract Our study underscores the potential of chlorine dioxide, resembling reactive oxygen species, in promoting tissue regeneration and executing similar functions. Direct intratumoral administration of chlorine dioxide conveniently and sustainably kills cancer cells, without the risk of developing drug resistance. Given that tumors are viewed as non-healing wounds, the regenerative capabilities of chlorine dioxide offer an innovative method to expedite wound healing and enhance patient outcomes in cancer treatment. Compared to traditional methods, chlorine dioxide treatment reduces complications and risks, presenting a safer alternative. Notably, higher concentrations of chlorine dioxide in promoting tumor ablation can particularly demonstrate the potential to disrupt tumor vasculature. We advocate for the intratumoral injection of chlorine dioxide to achieve direct tumor ablation and boost antitumor immunity while minimizing harm to healthy tissues. Although initial findings indicate that chlorine dioxide stimulates an antitumor immune response, further investigation is essential. As oncology advances with the use of immune checkpoint inhibitors, intratumoral chlorine dioxide administration emerges as a promising strategy, potentially extending survival and alleviating treatment burdens. Future research should focus on refining chlorine dioxide protocols, exploring synergistic therapies, and understanding its systemic immune effects, thereby establishing chlorine dioxide’s role in cancer therapy. Highlights Chlorine dioxide demonstrates potent ROS-like capabilities for both cancer elimination and tissue regeneration, offering a and effective treatment approach. Direct intratumoral administration of chlorine dioxide conveniently and sustainably kills cancer cells, without the risk of developing drug resistance. Chlorine dioxide can enhance tumor ablation potential by disrupting tumor vasculature, contributing to its overall effectiveness. Chlorine dioxide promotes an immune response against cancer, significantly enhancing its therapeutic effectiveness. Intratumoral injections of chlorine dioxide represent an innovative and promising strategy for efficacious cancer therapy.