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ERD2
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Abstract
erd2 mutants were isolated in a screen for cells that secrete proteins bearing the HDEL signal. The mutant cells show no recognition of HDEL, have no detectable defects in other protein sorting pathways and have wild-type growth rates under all conditions tested. However, the ERD2 gene is essential for growth. Depletion of Erd2p in cells leads to an accumulation of internal membranes and to a defect in the transport of proteins through the Golgi apparatus2 This may be due to a requirement for Erd2p in a forward transport step through the Golgi, or an indirect effect of the failure to recycle material from the Golgi back to the ER.
Title: ERD2
Description:
Abstract
erd2 mutants were isolated in a screen for cells that secrete proteins bearing the HDEL signal.
The mutant cells show no recognition of HDEL, have no detectable defects in other protein sorting pathways and have wild-type growth rates under all conditions tested.
However, the ERD2 gene is essential for growth.
Depletion of Erd2p in cells leads to an accumulation of internal membranes and to a defect in the transport of proteins through the Golgi apparatus2 This may be due to a requirement for Erd2p in a forward transport step through the Golgi, or an indirect effect of the failure to recycle material from the Golgi back to the ER.
Related Results
The K/HDEL receptor does not recycle, but instead acts as a Golgi-gatekeeper
The K/HDEL receptor does not recycle, but instead acts as a Golgi-gatekeeper
Abstract
The K/HDEL receptor (ER retention defective 2 or ERD2) does not recycle between compartments when sorting ER chaperones, contrary to the favoured model. A conserve...