PAGE2B is a prognostic marker for colorectal adenocarcinoma: bioinformatics analysis after correction for thyroid papillary carcinoma

Abstract Globally, Colon cancer has a high incidence and mortality rate, adenocarcinoma s is the most common pathological type. In this study, our objective was to explore a new biomarker for early diagnosis and prognosis in colorectal adenocarcinoma (COAD) patients. We downloaded mRNA data related to colorectal adenocarcinoma and thyroid papillary carcinoma through The Cancer Genome Atlas (TCGA) database, and used PTC as the mediator to explore the key genes causing the adverse prognosis of COAD. Univariate and multivariate Cox regression models were used, along with clinical information from COAD patients, to analyze the prognostic value of the target gene in COAD patients. Functional enrichment analysis was subsequently performed to elucidate the molecular mechanisms underlying the regulatory effects of the target gene on colorectal adenocarcinoma. We explore whether methylation is one of the causes of the high expression of target genes. Additionally, we calculated the percentage of infiltrating immune cells in COAD patients and evaluated their correlation with target gene expression. The potential sensitive drugs of target genes were explored by drug sensitivity analysis. Compared with those normal tissue, the gene expression levels of PAGE2B were found to be elevated in Compared with those colorectal adenocarcinoma tissues. Furthermore, the expression of PAGE2B in colorectal adenocarcinoma exhibited significant correlations with M stage. The results of functional enrichment analysis suggested the potential involvement of PAGE2B in the regulation of DAN methylation and cell cycle. Additionally, there were significant correlations between the expression level of the PAGE2B gene and the infiltration of various immune cells within the colon tumor microenvironment. PAGE2B can be used as a prognostic biomarker in patients with COAD could potentially be therapeutic target for COAD.