Antibacterial and Antifungal Activities of Various Extracts of Dianthus sylvestris subsp. aristidis (Batt) Greuter & Burdet

<p style="line-height:150%;margin-bottom:.0001pt;text-align:justify;text-indent:14.2pt;"><span style="line-height:150%;" lang="EN-US">In this study, we investigated the antibacterial and antifungal activities of&nbsp;hydro-methanolic (MeOH), ethyl acetate (EtOAc), and butanolic (n-BuOH) extracts&nbsp;from the leaves of </span><em><span style="line-height:150%;" lang="EN-US">Dianthus sylvestris</span></em><span style="line-height:150%;" lang="EN-US"> subsp. </span><em><span style="line-height:150%;" lang="EN-US">aristidis&nbsp;</span></em><span style="line-height:150%;" lang="EN-US">(Batt) Greuter &amp; Burdet against 78 clinical and 6 reference bacterial and fungal strains using disk diffusion to asses inhibition diameters (ID) and broth dilution methods to determine the minimum inhibitory concentration (MIC). The antimicrobial activity varied the extracts and strains, with interesting antibacterial effects against most tested bacterial strains. Inhibition diameters ranging from 10 to 20 mm,&nbsp;</span><span style="background-color:white;color:#0D0D0D;line-height:150%;" lang="EN-US">and MIC values varied between 31.25 and 1000 µg/mL</span><span style="line-height:150%;" lang="EN-US">. Furthermore, significant antifungal effects were observed, especially against </span><em><span style="line-height:150%;" lang="EN-US">Candida albicans</span></em><span style="line-height:150%;" lang="EN-US">, with ID ranging from 10 to 14 mm and MIC values ranging from 31.25 to 1000 µg/mL. All extracts showed growth inhibition percentages up to 100% against </span><em><span style="line-height:150%;" lang="EN-US">Aspergillus niger. &nbsp;</span></em><span style="line-height:150%;" lang="EN-US">These findings suggest that </span><em><span style="line-height:150%;" lang="EN-US">Dianthus sylvestris</span></em><span style="line-height:150%;" lang="EN-US"> subsp. </span><em><span style="line-height:150%;" lang="EN-US">aristidis</span></em><span style="line-height:150%;" lang="EN-US"> extracts are promising candidates for developing drugs against resistant pathogens.</span></p>