Knorr Pyrrole Synthesis

Abstract The synthesis of pyrrole derivatives by the condensation of α‐amino ketones with carbonyl compounds containing active α‐methylene groups is generally referred to as the Knorr pyrrole synthesis. This reaction is highly regioselective and always gives high yields of pyrrole derivatives. The study presents various conditions through which we can prevent the environmental hazards from this reaction when carried out on large scale. On the other hand, it has also been reported that even more pyrrole derivatives could be yielded if α‐amino ketone hydrochlorides are used directly rather than generated in situ .