Heterologous Corpuscular Anaphylaxis

Summary This paper furnishes proof for the theory of corpuscular anaphylaxis and disposes of the claim that the phenomenon is, in reality, due to small amounts of serum that may have been introduced with the corpuscles in the sensitizing and test doses. Sheep corpuscles sensitize guinea pigs to chicken corpuscles, and since sheep serum does not sensitize guinea pigs to chicken serum the conditions for serum anaphylaxis are excluded. An unsuspected difference between the rabbit and guinea pig in their anaphylactic behavior toward these cells comes to light. Chicken cells sensitize rabbits to sheep and goat cells, but sheep cells do not sensitize rabbits to chicken cells. The converse is true of the guinea pig. Sheep and goat cells sensitize guinea pigs to chicken cells but chicken cells do not sensitize to sheep and goat cells. The serum of the sheep and goat give cross reactions in guinea pigs, a relationship that holds for these corpuscles. The corpuscles of the sheep and goat, however, sensitize guinea pigs for chicken corpuscles. This relationship does not hold for sheep and goat sera, for they do not sensitize guinea pigs to chicken serum. Table 7 shows that anaphylaxis in the rabbit follows the behavior of the hemolytic antibody in its action toward chicken, sheep and goat cells. The phenomenon does not follow the behavior of the agglutinin toward these cells. In the guinea pig anaphylaxis does not follow the behavior of either the agglutinins or hemolysins toward the red cells of the chicken, sheep and goat. The death obtained in the guinea pigs with the red cells was typical of anaphylactic shock as evidenced by the onset of symptoms, the violent death and autopsy findings.