DIAGNOSIS VALUE OF SERUM COPEPTIN IN PATIENTS WITH ACUTE MYOCARRDIAL INFARCTION

Objective: To investigate the effectiveness of serum copeptin in the diagnosis of acute myocardial infarction. Patients: A total of 156 cases were enrolled in the study. All were over 18 years of age, and consisted of 78 AMI (31 STEMI and 47 NSTEMI) and 78 healthy subjects (controls). Methods: This was a cross sectional study with serum hs-Troponin I and copeptin were measured in each of the cases and were compared between the three groups for statistical differences. Results: (i) The serum hs-Troponin I and copeptin levels in the AMI group were found significantly higher than the control group. The mean serum copeptin of STEMI patients (0.93 ± 0.19 ng/mL) was higher than NSTEMI patients (0.72 ± 0.16 ng/mL); both were significantly elevated in compare with control group (0.52 ± 0.14 ng/ml); p < 0.001. (ii) The serum copeptin with a cut-off value of > 0.65 ng/mL had 70.51% sensitivity and 88.46% specificity (AUC 0.8891, 95% CI 0.84 – 0.94, p < 0.001). Conclusion: Serum copeptin had a high sensitivity and specificity in AMI diagnosis Key words: Copeptin, hs- Troponin I, Non-ST-segment elevation myocardial infarction, ST-Elevation myocardial infarction