Abstract 479: The role of diffusion in molecular networks: Diffusion coefficients in describing the development of cancer

Abstract To study and forecast the developments of cancers, the molecular networks, compositional fluctuations, diffusion in networks and altogether the biological processes resulting at cellular and intracellular levels, are highly important. Focusing on diffusion coefficients as the translational biomarkers to quantify the nucleation and growth of tumors and cancers has potential advantages. Because, diffusion coefficients act as guiding tools in preventing or treating the cancers and associated adversities. Collectively the biological, pharmacological and toxicological indicators during and prior to the course of cancer are taken as measures for the data over specific distances of the molecules to determine diffusion coefficients. Because, multiple mechanisms are simultaneously responsible in altering the compositions. In this work, the mass transportation in both healthy individuals and cancer patients are taken into account to compare and contrast the initiation and spread of cancers in the light of immunology and immunotherapy. Measurements through incoherent motion diffusion-weighted imaging (IVIM-DWI) and echo planar magnetic resonance (MR) imaging are applied in determining the diffusion parameters. Diffusion coefficients were within the ranges of 0.1 to 5 X 10-3 mm2/sec. Perfusion played important role in quantifications. Magnitudes of diffusion coefficients are used to forecast biological prevalence and to develop prevention and treatment therapeutics. Citation Format: Narayana Garimella. The role of diffusion in molecular networks: Diffusion coefficients in describing the development of cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 479.