Nur77 Inhibit β-catenin Expression to Mediate Hepatoblastoma Progression and Therapeutic Effect of Cisplatin

Abstract Hepatoblastoma (HB) is the most common malignant tumor in children under 5 years old, but its pathogenesis remains unclear. Nur77 has been reported to be an important regulator for cancer progression in various cancer types. This study found that Nur77 was downregulated in HB tumors, compared with paracancer tissue. Knockout or overexpression of Nur77 in HB tumor cell line HepG2 and HuH6 could significantly enhance or inhibit the proliferation, migration and invasion of tumor cells both in vitro and in vivo. Further studies illustrated that Nur77 regulated the proliferation of tumor cells by affecting the expression of β-catenin. Nur77 agonist Cns-A effectively enhanced the therapeutic effect of cisplatin on HB tumors both in vitro and in vivo. This study proved that Nur77 could act as a tumor suppressor gene in HB tumors, providing a new direction for improving the clinical responses of HB.