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EXPERIMENTAL RE-EVALUATION STUDIES ON ISONICOTINIC ACID HYDRAZIDE lN VITRO AND IN VIVO Ⅱ. Toxicity of isonicotinic Acid Hydrazide (INH) Against Mice
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The results of toxicity test of drugs in animals may not be fully applied to human beings, but generally toxicity and therapeutic doses of chemotherapeutic drugs in man are based on the results of experiments in animals. It is well known that the mouse is a useful animal for the purposes of estimation of antituberculous drugs. The following results were determined in our studied for the toxicity of INH in the uniform SM-strain mice: 1. Minimum lethal dose was 240mg per kg; by this dose of INH the average time of death was 52 minutes by oral administration and 32 minutes by subcutaneous injection. It seems that the direct cause of death comes from difficulty of breathing after toxic convulsions. 2. When the mice survived more than one hour after drug administration, in most cases of the experiment the mice did not die by acute intoxication of INH and completely returned to a normal healthy situation. 3. An administrable maximum dose once daily was 45mg per kg without causing loss of body weight of mice.
The Korean Academy of Tuberculosis and Respiratory Diseases
Title: EXPERIMENTAL RE-EVALUATION STUDIES ON ISONICOTINIC ACID HYDRAZIDE lN VITRO AND IN VIVO
Ⅱ. Toxicity of isonicotinic Acid Hydrazide (INH) Against Mice
Description:
The results of toxicity test of drugs in animals may not be fully applied to human beings, but generally toxicity and therapeutic doses of chemotherapeutic drugs in man are based on the results of experiments in animals.
It is well known that the mouse is a useful animal for the purposes of estimation of antituberculous drugs.
The following results were determined in our studied for the toxicity of INH in the uniform SM-strain mice: 1.
Minimum lethal dose was 240mg per kg; by this dose of INH the average time of death was 52 minutes by oral administration and 32 minutes by subcutaneous injection.
It seems that the direct cause of death comes from difficulty of breathing after toxic convulsions.
2.
When the mice survived more than one hour after drug administration, in most cases of the experiment the mice did not die by acute intoxication of INH and completely returned to a normal healthy situation.
3.
An administrable maximum dose once daily was 45mg per kg without causing loss of body weight of mice.
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