Javascript must be enabled to continue!

Data from Stromal LRP1 in Lung Adenocarcinoma Predicts Clinical Outcome

<div>AbstractPurpose: LRP1 (low-density lipoprotein receptor–related protein 1) is a broadly expressed receptor that binds multiple extracellular ligands and participates in protein clearance. It is expressed in numerous cancers, but its role in lung cancer has not been characterized. Here, we investigate the relationship between LRP1 and lung cancer.Experimental Design:LRP1 mRNA levels were determined in lung tumors from several large, multicenter studies. LRP1 protein localization was determined by immunohistochemical analysis of lung tumor microarrays. Normal fibroblasts, fibroblasts treated with the LRP1 inhibitor RAP (receptor-associated protein), and Lrp1 null fibroblasts were cocultured with 3 independent lung cancer cell lines to investigate the role of LRP1 on tumor cell proliferation.Results:LRP1 mRNA levels are significantly decreased in lung tumors relative to nontumorous lung tissue. Lower expression of LRP1 in lung adenocarcinomas correlates with less favorable clinical outcome in a cohort of 439 patients. Immunohistochemical analysis shows that LRP1 is primarily expressed in stromal cells in 94/111 lung cancers, with very little protein found in cancer cells. A growth-suppressive function of mouse embryonic fibroblast (MEF) cells was observed in 3 lung cancer cell lines tested (H460, H2347, and HCC4006 cells); growth suppression was blocked by the LRP1 inhibitor RAP. Lrp1 deletion in fibroblasts reduced the ability of MEF cells to suppress tumor cell mitosis. In a validation set of adenocarcinomas, we confirmed a significant, positive correlation between both LRP1 mRNA and protein levels and favorable clinical outcomes.Conclusions:LRP1 expression is associated with improved lung cancer outcomes. Mechanistically, stromal LRP1 may non–cell autonomously suppress lung tumor cell proliferation. Clin Cancer Res; 17(8); 2426–33. ©2011 AACR.</div>

American Association for Cancer Research (AACR)

He Meng Guoan Chen Xiaojie Zhang Zhuwen Wang Dafydd G. Thomas Thomas J. Giordano David G. Beer Michael M. Wang

2023

Title: Data from Stromal LRP1 in Lung Adenocarcinoma Predicts Clinical Outcome

Description:

It is expressed in numerous cancers, but its role in lung cancer has not been characterized.

Here, we investigate the relationship between LRP1 and lung cancer.

Experimental Design:LRP1 mRNA levels were determined in lung tumors from several large, multicenter studies.

LRP1 protein localization was determined by immunohistochemical analysis of lung tumor microarrays.

Normal fibroblasts, fibroblasts treated with the LRP1 inhibitor RAP (receptor-associated protein), and Lrp1 null fibroblasts were cocultured with 3 independent lung cancer cell lines to investigate the role of LRP1 on tumor cell proliferation.

Results:LRP1 mRNA levels are significantly decreased in lung tumors relative to nontumorous lung tissue.

Lower expression of LRP1 in lung adenocarcinomas correlates with less favorable clinical outcome in a cohort of 439 patients.

Immunohistochemical analysis shows that LRP1 is primarily expressed in stromal cells in 94/111 lung cancers, with very little protein found in cancer cells.

A growth-suppressive function of mouse embryonic fibroblast (MEF) cells was observed in 3 lung cancer cell lines tested (H460, H2347, and HCC4006 cells); growth suppression was blocked by the LRP1 inhibitor RAP.

Lrp1 deletion in fibroblasts reduced the ability of MEF cells to suppress tumor cell mitosis.

In a validation set of adenocarcinomas, we confirmed a significant, positive correlation between both LRP1 mRNA and protein levels and favorable clinical outcomes.

Conclusions:LRP1 expression is associated with improved lung cancer outcomes.

Mechanistically, stromal LRP1 may non–cell autonomously suppress lung tumor cell proliferation.

Clin Cancer Res; 17(8); 2426–33.

</div>.

Back

<div>AbstractPurpose: LRP1 (low-density lipoprotein receptor–related protein 1) is a broadly expressed receptor that binds multiple extracellular ...

Minimally Invasive Thoracoscopic Surgery of Lung Adenocarcinoma in Old Age People

Background: Lung cancer is the most frequent human malignancy and the principal cause of cancer-related death worldwide. Adenocarcinoma is now the main histologic type, accounting ...

USP4 promotes proliferation and metastasis in human lung adenocarcinoma

Abstract Objective Research the expression of USP4 in lung adenocarcinoma and its correlation with clinicopathological features and prognosis analysis, to explore the inva...

Microwave Ablation with or Without Chemotherapy in Management of Non-Small Cell Lung Cancer: A Systematic Review

Abstract Introduction Microwave ablation (MWA) has emerged as a minimally invasive treatment for patients with inoperable non-small cell lung cancer (NSCLC). However, whether it i...

Small Cell Lung Cancer and Tarlatamab: A Meta-Analysis of Clinical Trials

Abstract Introduction Tarlatamab is a Delta-like ligand 3 (DLL3) -directed bispecific T-cell engager recently approved for use in patients with advanced small cell lung cancer (SCL...

Abstract 1657: Genome-wide association study of lung cancer: Variation in TP63 gene confers the risk of lung adenocarcinoma

Abstract Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. Lung cancer compri...

Experience Sharing in Pathological Diagnosis of Early Adenocarcinoma of the Lung

Background: In daily work, there are still many pathologists who have difficulty handling the diagnosis of atypical adenomatous hyperplasia, adenocarcinoma in situ, minimally invas...

Blunt Chest Trauma and Chylothorax: A Systematic Review

Abstract Introduction: Although traumatic chylothorax is predominantly associated with penetrating injuries, instances following blunt trauma, as a rare and challenging condition, ...

Email:
Password:

Email:

Data from Stromal LRP1 in Lung Adenocarcinoma Predicts Clinical Outcome

Related Results