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Supplementary Figures 1 - 6 from ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38
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<p>PDF file - 840K, Suppl. Figure 1. Conversion of CPT-11 (irinotican) to SN-38 by carboxylesterase; Suppl. Figure 2. Western blot analysis of the basal expression status of ACLy in a panel of colon cancer cell (CRC) lines; Suppl. Figure 3. Overexpression of fatty acid synthase (FASN) inhibited ACLy inhibition induced sensitization of HT29 cells to SN38; Suppl. Figure 4. Increased lipid droplets in HT29 cells that are resistant to SN38 (HT29-SNR) or oxaliplatin (HT29-OxR); Suppl. Figure 5. HT29-SNR cells exhibited enhanced de novo lipogenesis; Suppl. Figure 6. Co-targeting ACLy and AKT re-sensitized HT29-SNR cells to SN38.</p>
American Association for Cancer Research (AACR)
Title: Supplementary Figures 1 - 6 from ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38
Description:
<p>PDF file - 840K, Suppl.
Figure 1.
Conversion of CPT-11 (irinotican) to SN-38 by carboxylesterase; Suppl.
Figure 2.
Western blot analysis of the basal expression status of ACLy in a panel of colon cancer cell (CRC) lines; Suppl.
Figure 3.
Overexpression of fatty acid synthase (FASN) inhibited ACLy inhibition induced sensitization of HT29 cells to SN38; Suppl.
Figure 4.
Increased lipid droplets in HT29 cells that are resistant to SN38 (HT29-SNR) or oxaliplatin (HT29-OxR); Suppl.
Figure 5.
HT29-SNR cells exhibited enhanced de novo lipogenesis; Suppl.
Figure 6.
Co-targeting ACLy and AKT re-sensitized HT29-SNR cells to SN38.
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