Abstract 6226: Chinese visceral adiposity index outperforms other obesity indexes in association with increased overall cancer incidence: Findings from prospective MJ cohort study

Abstract Background: Chinese Visceral Adiposity Index (CVAI) is an integrated index to measure visceral adiposity tissue (VAT). This study is to assess the relationship between VAT indices such as CVAI, Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP) waist circumference (WC) and waist-hip ratio (WHR) with overall and specific cancer incidence in Chinese. Methods: 332, 297 individuals from the MJ cohort were tracked from 1996 to 2007. We utilized multivariable Cox proportional hazards models to examine the connections of five baseline visceral obesity indices and cancer incidence. Results: A robust dose-response correlation between CVAI and the risk of overall cancer incidence was observed. The HRs were 1.45 (95% CI: 1.2-1.76) and 2.03 (95% CI: 1.52-2.72) for males and females when comparing Quintile 5 to the reference. The HRs for WC were 1.27 (95% CI: 1.08-1.49) among males and 1.19 (95% CI: 1.01-1.40) among females, and WHR showed significance in males (HR:1.28; 95% CI: 1.13-1.45), LAP showed significance in females (HR: 1.25; 95% CI: 1.04-1.5). VAI was not related to overall cancer incidence. Conclusion: The results support CVAI's practicality as a superior clinical marker for predicting cancer incidence in the Chinese population compared to traditional central obesity indices. Citation Format: Mengying Wang, Chi Pang Wen, David Ta-Wei Chu, Huakang Tu, Wenyuan Li, Xifeng Wu. Chinese visceral adiposity index outperforms other obesity indexes in association with increased overall cancer incidence: Findings from prospective MJ cohort study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6226.