Advancing point-of-care diagnostics through nanotechnology: A focus on low-cost solutions for rural healthcare

The development of portable diagnostic devices for early detection of zoonotic diseases is critical in advancing public health through a One Health approach. Zoonotic diseases, which are transmitted between animals and humans, pose significant threats to global health security due to their potential to cause widespread outbreaks. Early detection and rapid response are essential in mitigating the impact of these diseases. Portable diagnostic devices offer a practical and effective solution by enabling on-site testing in remote and resource-limited settings. These devices leverage advanced technologies such as microfluidics, biosensors, and molecular diagnostics to provide accurate and timely results, facilitating immediate intervention and treatment. The integration of a One Health approach in the development and deployment of these devices underscores the interconnection between human, animal, and environmental health. By focusing on the early detection of zoonotic diseases at the human-animal-environment interface, portable diagnostic devices contribute to preventing the spread of infections and reducing the risk of pandemics. This approach also emphasizes the importance of collaboration across disciplines, including veterinary science, medicine, and environmental health, to create comprehensive strategies for disease control. Recent advancements in portable diagnostics have led to the creation of devices that are not only cost-effective and easy to use but also capable of detecting multiple pathogens simultaneously. These innovations have the potential to transform disease surveillance and response, particularly in regions where traditional laboratory infrastructure is lacking. However, challenges remain in ensuring the accessibility, affordability, and reliability of these devices across diverse settings. In conclusion, the development of portable diagnostic devices for early detection of zoonotic diseases represents a significant advancement in global health, particularly when integrated with the One Health approach. These devices have the potential to enhance disease surveillance, improve public health outcomes, and prevent zoonotic outbreaks, ultimately contributing to a more resilient and proactive global health system. Continued research, innovation, and interdisciplinary collaboration will be crucial in realizing the full potential of these technologies in safeguarding public health. Keywords: Point-of-Care, Diagnostics, Nanotechnology, Low-Cost Solutions, Rural Healthcare.