Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Analysis of Tacrolimus Clearance in Patients with Kidney Transplants from Romania
View through CrossRef
Background/Objectives: Tacrolimus is a key immunosuppressant in kidney transplantation, but its high interindividual pharmacokinetic variability complicates dosing. This study aimed to develop a population pharmacokinetic model and identify the factors explaining variability to optimize tacrolimus therapy in Romanian kidney transplant recipients. Methods: The study included 106 kidney transplant recipients treated at Fundeni Clinical Institute (2022–2024). Tacrolimus blood levels were measured using immunoassays, while gene polymorphisms of CYP3A4, CYP3A5, and ABCB1 were identified by real-time polymerase chain reaction. Results: Patients with CYP3A4*1/*1.001 impact clearance (RSE = 11.8%), while hematocrit was a significant covariate for intercompartmental clearance (RSE = 6.14%). Conclusions: Incorporating CYP3A4*1/*1.001 genotype and hematocrit into dosing strategies can improve therapeutic drug monitoring and personalize immunosuppressive therapy.
Title: Analysis of Tacrolimus Clearance in Patients with Kidney Transplants from Romania
Description:
Background/Objectives: Tacrolimus is a key immunosuppressant in kidney transplantation, but its high interindividual pharmacokinetic variability complicates dosing.
This study aimed to develop a population pharmacokinetic model and identify the factors explaining variability to optimize tacrolimus therapy in Romanian kidney transplant recipients.
Methods: The study included 106 kidney transplant recipients treated at Fundeni Clinical Institute (2022–2024).
Tacrolimus blood levels were measured using immunoassays, while gene polymorphisms of CYP3A4, CYP3A5, and ABCB1 were identified by real-time polymerase chain reaction.
Results: Patients with CYP3A4*1/*1.
001 impact clearance (RSE = 11.
8%), while hematocrit was a significant covariate for intercompartmental clearance (RSE = 6.
14%).
Conclusions: Incorporating CYP3A4*1/*1.
001 genotype and hematocrit into dosing strategies can improve therapeutic drug monitoring and personalize immunosuppressive therapy.
Related Results
Ranolazine-Tacrolimus Interaction
Ranolazine-Tacrolimus Interaction
Objective: To report the case of a kidney allograft recipient on a stable regimen of tacrolimus who exhibited increased tacrolimus concentrations within 24 hours of initiating rano...
Heart and Lung Transplantation in India: Results of the Indian Heart Lung Transplant Registry of Indian Society for Heart and Lung Transplant: 2025
Heart and Lung Transplantation in India: Results of the Indian Heart Lung Transplant Registry of Indian Society for Heart and Lung Transplant: 2025
Introduction:
The Indian Society of Heart and Lung Transplantation (INSHLT) maintains the registry of thoracic organ transplants done in India. This report highlights t...
Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells
Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells
Background
Topical tacrolimus has been used for vitiligo as a common treatment option for more than ten years while the underlying mechanism is still uncertain. The aim...
Population Pharmacokinetics Study of Tacrolimus in Chinese Hematopoietic Cell Transplant Patients.
Population Pharmacokinetics Study of Tacrolimus in Chinese Hematopoietic Cell Transplant Patients.
Abstract
Abstract 4668
Background
The use of tacrolimus is complicated by its narrow therapeutic index and wide i...
Comparison of Tacrolimus Intra-Patient Variability during 6–12 Months after Kidney Transplantation between CYP3A5 Expressers and Nonexpressers
Comparison of Tacrolimus Intra-Patient Variability during 6–12 Months after Kidney Transplantation between CYP3A5 Expressers and Nonexpressers
A high intra-patient variability (IPV) of tacrolimus exposure is associated with poor long-term kidney transplantation outcomes. To assess the influence of cytochrome P450 (CYP) 3A...
Non-Inferiority of Dual Kidney Transplantation: A Retrospective Matched Study
Non-Inferiority of Dual Kidney Transplantation: A Retrospective Matched Study
Background/Objectives: Dual kidney transplantation is a potential technique to reduce the number of discarded kidneys from expanded-criteria donors. Due to allegedly poor outcomes,...
Tacrolimus-Induced Leukoencephalopathy in a Renal Transplantation Patient
Tacrolimus-Induced Leukoencephalopathy in a Renal Transplantation Patient
Tacrolimus is an immunosuppressant that is frequently used following renal transplantation. Several mild neurological side effects of tacrolimus have been reported in the literatur...
Semen analysis of renal transplant patients undergoing immunosuppressive treatment
Semen analysis of renal transplant patients undergoing immunosuppressive treatment
Introduction The prevalence of infertility is increasing at an alarming rate globally. Many couples are afflicted with infertility due to an array of diseases, trauma and psycholog...