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Swapping of transmembrane domains in the epithelial calcium channel TRPV6
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Abstract
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement
in vivo
, affecting its function in normal or disease states.
Title: Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Description:
Abstract
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains.
Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold.
These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement
in vivo
, affecting its function in normal or disease states.
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