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Enzymatic method for determining in vivo the mineralizing efficiency of osteoprotective drugs
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For screening osteoprotectors, it is proposed to investigate the mineralizing activity of rat bone tissue (femur, jaws, teeth) in which experimental osteoporosis was reproduced (stress, inadequate nutrition, dysmetabolic syndrome). It is proposed to determine the mineralizing activity by the ratio of alkaline (ALP) and acid (AP) phosphatase activity in bone tissue.
It is proposed to determine in vivo the mineralizing efficiency of the drug by the percentage increase in mineralizing activity per dose of the drug in mg/kg of live weight.
Of the three osteoprotectors studied (EkSoVit, quercetin and ascorbic acid), quercetin was the most effective, and ascorbic acid was the least effective.
Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
Title: Enzymatic method for determining in vivo the mineralizing efficiency of osteoprotective drugs
Description:
For screening osteoprotectors, it is proposed to investigate the mineralizing activity of rat bone tissue (femur, jaws, teeth) in which experimental osteoporosis was reproduced (stress, inadequate nutrition, dysmetabolic syndrome).
It is proposed to determine the mineralizing activity by the ratio of alkaline (ALP) and acid (AP) phosphatase activity in bone tissue.
It is proposed to determine in vivo the mineralizing efficiency of the drug by the percentage increase in mineralizing activity per dose of the drug in mg/kg of live weight.
Of the three osteoprotectors studied (EkSoVit, quercetin and ascorbic acid), quercetin was the most effective, and ascorbic acid was the least effective.
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