Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Invadopodia Related‐Proteins Expression in Mucoepidermoid Carcinoma
View through CrossRef
ABSTRACT
Objective
This study aimed to assess the expression of invadopodia‐related proteins in mucoepidermoid carcinoma and their influence on this tumor's invasiveness.
Material and Methods
Twenty‐seven mucoepidermoid carcinoma grading samples were evaluated for the expression of Tks4, Tks5, cortactin, and MT1‐MMP and compared to 10 control samples of normal‐looking salivary glands by immunohistochemistry. For in vitro analysis, immunofluorescence identified the expression of invadopodia‐related proteins in the mucoepidermoid carcinoma cell line. Invadopodia formation and invasion assays were performed after silencing of Tks4 and Tks5 to evaluate invasiveness.
Results
The invadopodia‐related proteins were expressed significantly higher in mucoepidermoid carcinoma samples when compared to the control group. Positive expression of these proteins was identified in the mucoepidermoid carcinoma cell line. Knockdown of Tks4 and Tks5 reduced both gelatin degradation and invadopodia activity in mucoepidermoid carcinoma cell lines.
Conclusion
Our results suggest that mucoepidermoid carcinoma behavior can be mediated by the expression of invadopodia‐related proteins. Tks4 and Tks5 play a role in the invasiveness of mucoepidermoid carcinoma, mediated by invadopodia.
Title: Invadopodia Related‐Proteins Expression in Mucoepidermoid Carcinoma
Description:
ABSTRACT
Objective
This study aimed to assess the expression of invadopodia‐related proteins in mucoepidermoid carcinoma and their influence on this tumor's invasiveness.
Material and Methods
Twenty‐seven mucoepidermoid carcinoma grading samples were evaluated for the expression of Tks4, Tks5, cortactin, and MT1‐MMP and compared to 10 control samples of normal‐looking salivary glands by immunohistochemistry.
For in vitro analysis, immunofluorescence identified the expression of invadopodia‐related proteins in the mucoepidermoid carcinoma cell line.
Invadopodia formation and invasion assays were performed after silencing of Tks4 and Tks5 to evaluate invasiveness.
Results
The invadopodia‐related proteins were expressed significantly higher in mucoepidermoid carcinoma samples when compared to the control group.
Positive expression of these proteins was identified in the mucoepidermoid carcinoma cell line.
Knockdown of Tks4 and Tks5 reduced both gelatin degradation and invadopodia activity in mucoepidermoid carcinoma cell lines.
Conclusion
Our results suggest that mucoepidermoid carcinoma behavior can be mediated by the expression of invadopodia‐related proteins.
Tks4 and Tks5 play a role in the invasiveness of mucoepidermoid carcinoma, mediated by invadopodia.
Related Results
Complex Collision Tumors: A Systematic Review
Complex Collision Tumors: A Systematic Review
Abstract
Introduction: A collision tumor consists of two distinct neoplastic components located within the same organ, separated by stromal tissue, without histological intermixing...
Breast Carcinoma within Fibroadenoma: A Systematic Review
Breast Carcinoma within Fibroadenoma: A Systematic Review
Abstract
Introduction
Fibroadenoma is the most common benign breast lesion; however, it carries a potential risk of malignant transformation. This systematic review provides an ove...
Hypoxia-induced invadopodia formation: a role for β-PIX
Hypoxia-induced invadopodia formation: a role for β-PIX
During tumour progression, oxygen tension in the microenvironment surrounding tumour cells is reduced, resulting in hypoxia. It is well established that cancer cells resist the neg...
A role for YAP-mediated regulation of invadopodia in HNSCC cells
A role for YAP-mediated regulation of invadopodia in HNSCC cells
ABSTRACTThe objective of this study was to determine whether nuclear translocation of the transcriptional coactivator Yes-associated protein (YAP) was sensitive to extracellular ma...
Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands
Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands
CONTEXT: Among the cytological and morphological properties of mucoepidermoid carcinoma, one of the most important criteria for measuring its biological behavior and aggressiveness...
Data from CDCP1 Regulates the Function of MT1-MMP and Invadopodia-Mediated Invasion of Cancer Cells
Data from CDCP1 Regulates the Function of MT1-MMP and Invadopodia-Mediated Invasion of Cancer Cells
<div>Abstract<p>Complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing protein 1 (CDCP1) is a transmembrane protein that regulates anchorage-independent growth and canc...
Data from CDCP1 Regulates the Function of MT1-MMP and Invadopodia-Mediated Invasion of Cancer Cells
Data from CDCP1 Regulates the Function of MT1-MMP and Invadopodia-Mediated Invasion of Cancer Cells
<div>Abstract<p>Complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing protein 1 (CDCP1) is a transmembrane protein that regulates anchorage-independent growth and canc...
Pulmonary mucoepidermoid carcinoma with endobronchial involvement: A case report
Pulmonary mucoepidermoid carcinoma with endobronchial involvement: A case report
Although mucoepidermoid carcinomas (MEC) commonly occur in the salivary glands, they are rarely encountered in the lungs. In this case report, we present a rare case of pulmonary m...