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Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses
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AbstractCa2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca2+ influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca2+ rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro‐inflammatory molecule LTC4. In addition, local Ca2+ entry can activate gene expression, which develops over tens of minutes. Local Ca2+ influx through CRAC channels therefore has far‐reaching consequences on intra‐ and intercellular communication.
Title: Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses
Description:
AbstractCa2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels controls a disparate array of key cellular responses.
In this review, recent work will be described that shows local Ca2+ influx through CRAC channels has important spatial and temporal consequences on cell function.
A localized Ca2+ rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro‐inflammatory molecule LTC4.
In addition, local Ca2+ entry can activate gene expression, which develops over tens of minutes.
Local Ca2+ influx through CRAC channels therefore has far‐reaching consequences on intra‐ and intercellular communication.
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