Nitrosative stress in adolescents with exogenous constitutional obesity

Objective. To study the levels of nitric oxide, advanced oxidation protein products and total antioxidant activity in serum and plasma in adolescents with exogenous constitutional obesity. Patients and methods. The study group included 46 adolescents with class I exogenous constitutional obesity (24 girls and 22 boys). The control group included 43 adolescents with normal body weight (23 girls and 20 boys). The levels of nitric oxide, advanced oxidation protein products and total antioxidant activity in serum and plasma were determined by spectrophotometry. Results. There were no statistically significant differences between groups in metabolic indices. In adolescent boys with obesity, a direct correlation was found between the levels of nitric oxide and advanced oxidation protein products, and between the levels of nitric oxide and total antioxidant activity. Conclusion. In the group of adolescent boys with class I exogenous constitutional obesity, the formation of pathogenetic interrelations between the parameters of nitrosative status was observed, which indicates the initial signs of metabolic changes. Key words: obesity, adolescents, free radical oxidation, nitric oxide