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Gold‐Catalyzed Synthesis of Substituted 4‐Pentafluorosulfanyl‐1,3‐Oxazoles
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This work reports the first synthesis of pentafluorosulfanylated oxazoles through a gold(I)‐catalyzed cyclization of SF5‐alkynes and nitriles. It describes 18 examples of 4‐SF5‐oxazoles with NMR yield ranging from 3% to 75%. While the isolation of the pure pentafluorosulfanylated oxazoles proves challenging, the fluorinated heterocycles can nonetheless be obtained in yields between 14% and 52%, opening the door for their use as a novel fluorine‐containing scaffold.
Title: Gold‐Catalyzed Synthesis of Substituted 4‐Pentafluorosulfanyl‐1,3‐Oxazoles
Description:
This work reports the first synthesis of pentafluorosulfanylated oxazoles through a gold(I)‐catalyzed cyclization of SF5‐alkynes and nitriles.
It describes 18 examples of 4‐SF5‐oxazoles with NMR yield ranging from 3% to 75%.
While the isolation of the pure pentafluorosulfanylated oxazoles proves challenging, the fluorinated heterocycles can nonetheless be obtained in yields between 14% and 52%, opening the door for their use as a novel fluorine‐containing scaffold.
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