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Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe
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Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.
Title: Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe
Description:
Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes.
Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies.
Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing.
7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity.
The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.
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