Is Smoking an Unfavorable Prognostic Factor for Rheumatoid Arthritis?

Abstract Introduction: Smoking is the environmental factor that plays the most important role in the etiology of rheumatoid arthritis and the only one that can be changed. In rheumatoid arthritis patients, smoking results in erosive, rapidly progressive, poor therapeutic response. There are studies suggesting that auto antibodies (rheumatoid factor and anti citrullinated protein antibodies) production is triggered by exposure to smoking, thus contributing to rheumatoid arthritis. Objectives: In this study we have proposed to analyze the effects of smoking on the rheumatoid arthritis. Methods: We evaluated 285 patients with RA admitted to Department of Rheumatology, Clinical Emergency Hospital “St. Andrew”, Constanţa during January-December 2013. Demographics of patients and data on the onset and progression of RA were followed. We were particularly interested in the data related to the rheumatoid arthritis prognostic factors as they were established and published by the Romanian Rheumatology Society. Conclusion: Smoking influences the onset of rheumatoid arthritis, the seropositivity, the presence of extraarticular manifestations, the acute phase reactants and the number of swollen joints. We can therefore conclude that smoking is an unfavorable prognostic factor for rheumatoid arthritis, influencing both the onset and its evolution.