Correlation of Serum Ferritin Levels and Liver Function Tests with ABO Blood Grouping

This study was carried out to evaluate the association between serum ferritin, liver function parameters, and ABO blood grouping. A total of eighty (80) subjects were recruited, comprising nineteen (19) individuals with blood group A, fifteen (15) with blood group B, sixteen (16) with blood group AB, and thirty (30) with blood group O. Blood samples were collected from the antecubital vein into accurately labeled heparinized bottles for each participant and transported to the laboratory for the estimation of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, and albumin. Both ABO and Rhesus blood groups were determined using the tube method. The results of this study revealed that serum ALT activity differed significantly (p < 0.05) among the various blood groups. Pairwise comparison showed that ALT levels were significantly different (p < 0.05) in blood groups B and AB when compared with groups A and O. However, the serum activities of AST and ALP did not differ significantly (p > 0.05) among the blood groups, although AST was higher in blood group AB and ALP was higher in blood group O. Similarly, pairwise comparisons for these enzymes were also not significantly different (p > 0.05). Serum total protein and albumin levels were not significantly different (p > 0.05) across the blood groups; total protein was higher in blood group AB, while albumin was higher in blood group B. Serum ferritin levels were likewise not significantly different (p > 0.05) among the blood groups, although higher values were observed in blood group AB compared with the others. This study, therefore, suggests that, although most liver function and ferritin parameters did not show statistically significant differences across ABO blood groups, there are observable trends indicating that these parameters may vary among individuals with different ABO phenotypes.