Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Expression of keratinocyte growth factor and its receptor in odontogenic keratocysts
View through CrossRef
Background: The mitotic activity of the epithelial cells of odontogenic keratocysts (OKCs) is greater than that of other odontogenic jaw cysts, and the mitotic activity of the epithelial cells decreases after marsupialization. Keratinocyte growth factor (KGF) interacts with its specific receptor (KGFR), and elicits the proliferation and/or differentiation of the various types of epithelial cells. The aim of this study was to investigate the expression of KGF/KGFR in OKCs before and after marsupialization.Methods: The expression of KGF was immunohistochemically detected in the specimens of 16 OKCs and 11 dentigerous cysts before and after marsupialization. The expression of KGF mRNA was measured in the fibroblasts isolated from OKCs by real‐time PCR.Results: KGF was expressed in the epithelial cells and fibroblasts of 12 and seven of 16 OKC specimens, respectively. The intensity of the KGF expression in both the epithelial cells and the fibroblasts significantly decreased after marsupialization. KGFR was expressed throughout the epithelium in 15 of 16 OKC specimens, but the intensity of the KGFR expression did not change after marsupialization. The expression of KGF was detected in the epithelium of two of 11 dentigerous cyst specimens, but not in the fibroblasts before marsupialization. Real‐time PCR revealed that recombinant human interleukin (IL)‐1α increased the expression of KGF mRNA in the fibroblasts isolated from OKCs.Conclusion: KGF/KGFR signaling may play a crucial role in the epithelial cells of OKCs. Furthermore, the expression of KGF in the fibroblasts of OKCs is regulated by IL‐1α.
Title: Expression of keratinocyte growth factor and its receptor in odontogenic keratocysts
Description:
Background: The mitotic activity of the epithelial cells of odontogenic keratocysts (OKCs) is greater than that of other odontogenic jaw cysts, and the mitotic activity of the epithelial cells decreases after marsupialization.
Keratinocyte growth factor (KGF) interacts with its specific receptor (KGFR), and elicits the proliferation and/or differentiation of the various types of epithelial cells.
The aim of this study was to investigate the expression of KGF/KGFR in OKCs before and after marsupialization.
Methods: The expression of KGF was immunohistochemically detected in the specimens of 16 OKCs and 11 dentigerous cysts before and after marsupialization.
The expression of KGF mRNA was measured in the fibroblasts isolated from OKCs by real‐time PCR.
Results: KGF was expressed in the epithelial cells and fibroblasts of 12 and seven of 16 OKC specimens, respectively.
The intensity of the KGF expression in both the epithelial cells and the fibroblasts significantly decreased after marsupialization.
KGFR was expressed throughout the epithelium in 15 of 16 OKC specimens, but the intensity of the KGFR expression did not change after marsupialization.
The expression of KGF was detected in the epithelium of two of 11 dentigerous cyst specimens, but not in the fibroblasts before marsupialization.
Real‐time PCR revealed that recombinant human interleukin (IL)‐1α increased the expression of KGF mRNA in the fibroblasts isolated from OKCs.
Conclusion: KGF/KGFR signaling may play a crucial role in the epithelial cells of OKCs.
Furthermore, the expression of KGF in the fibroblasts of OKCs is regulated by IL‐1α.
Related Results
Marsupialization inhibits interleukin‐1α expression and epithelial cell proliferation in odontogenic keratocysts
Marsupialization inhibits interleukin‐1α expression and epithelial cell proliferation in odontogenic keratocysts
AbstractBackground: Marsupialization results in the reduction of odontogenic cyst size. Interleukin‐1α (IL‐1α) is thought to play a crucial role for the expansion of odontogenic ...
Magnetic resonance imaging signal intensity in the characterization of odontogenic lesions: a systematic review
Magnetic resonance imaging signal intensity in the characterization of odontogenic lesions: a systematic review
Odontogenic lesions content can be differed using magnetic resonance imaging (MRI) signal intensity (SI). Objective: This systematic literature review addresses the use of MRI SI f...
Odontogenic Diseases And Disorders Of Infectious Nature In Relation To Paediatric Population–A systematic review
Odontogenic Diseases And Disorders Of Infectious Nature In Relation To Paediatric Population–A systematic review
Background: Most Odontogenic tumors that affect children and adolescents are benign and constitute about 1% to as high as 28% of all oral lesions in children. It is important to kn...
The Reduction of JunB Inhibits the Odontogenic Differentiation Potential of the DPSCs by Targeting PIN1 in Pulpitis
The Reduction of JunB Inhibits the Odontogenic Differentiation Potential of the DPSCs by Targeting PIN1 in Pulpitis
Abstract
Pulpitis is an inflammatory condition that can lead to the loss of tooth vitality. The odontogenic differentiation potential of the dental pulp stem cells (DPSCs) ...
Severe odontogenic infections with septic progress - a constant and increasing challenge
Severe odontogenic infections with septic progress - a constant and increasing challenge
Abstract
Objective
More than 90% of all infections of the head and neck region can be traced back to an odontogenic origin. In rare cases they can lead to sepsis, which ma...
Severe odontogenic infections with septic progress - a constant and increasing challenge: a retrospective analysis
Severe odontogenic infections with septic progress - a constant and increasing challenge: a retrospective analysis
Abstract
ABSTRACT
Background
More than 90% of all infections in the head and neck region can be traced back to an odontogenic origin. In rare cases they can lead to sepsis,...
Severe odontogenic infections with septic progress - a constant and increasing challenge: a retrospective analysis
Severe odontogenic infections with septic progress - a constant and increasing challenge: a retrospective analysis
Abstract
ABSTRACT
Background
More than 90% of all infections in the head and neck region can be traced back to an odontogenic origin. In rare cases they can lead to sepsis,...
Receptor-dependent internalization of platelet-activating factor.
Receptor-dependent internalization of platelet-activating factor.
Abstract
A human neutrophil platelet-activating factor (PAF) receptor expressed in transfected cells was utilized to study receptor-dependent interactions with the l...