Osobennosti kardioprotektivnogo deystviyazofenoprila vo vtorichnoy profilaktikeserdechno-sosudistykh zabolevaniy

Summary. Zofenopril is one of the most recent ACE inhibitors; it shows a high lipophilicity. This property determines its high and rapid absorption, a considerable proportion of excretion with bile and improved tissue permeability associated with the prolonged effect of tissue ACE inhibition. This property must underlie some effects of zofenopril, which are absent in other drugs of this class. Thus, the combination of lipophilicity and antioxidant activity ensures the optimal antihypertensive efficacy along with antiatherogenic activity. These two latter properties most probably make a major contribution to a reduction in death rates after myocardial infarction, as conclusively demonstrated in a series of SMILE clinical trials. The above properties of zofenopril support once again the idea that not all ACE inhibitors are equally effective in the treatment of arterial hypertension and in secondary prevention after myocardial infarction.