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Making Connections
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T cells respond to antigen through multiple signals, many of which are driven by proteins that coassociate at the cell membrane. SLP-76 is a primary signaling molecule that is recruited by the integral membrane protein LAT, and together they initiate several signaling pathways. Yoder
et al.
show that GADS, a small adaptor protein, is critical in mediating this association and thus has a significant impact on T cell development. Thymocytes from mice deficient in the expression of GADS displayed defects in cellular proliferation, as well as in positive and negative selection. By connecting SLP-76 and LAT, GADS facilitates important SLP-76-dependent signals at different stages of T cell development.
J. Yoder, C. Pham, Y.-M. Iizuka, O. Kanagawa, S. K. Liu, J. McGlade, A. M. Cheng, Requirement for the SLP-76 adaptor GADS in T cell development.
Science
291
, 1987-1991 (2001).
[Abstract]
[Full Text]
Title: Making Connections
Description:
T cells respond to antigen through multiple signals, many of which are driven by proteins that coassociate at the cell membrane.
SLP-76 is a primary signaling molecule that is recruited by the integral membrane protein LAT, and together they initiate several signaling pathways.
Yoder
et al.
show that GADS, a small adaptor protein, is critical in mediating this association and thus has a significant impact on T cell development.
Thymocytes from mice deficient in the expression of GADS displayed defects in cellular proliferation, as well as in positive and negative selection.
By connecting SLP-76 and LAT, GADS facilitates important SLP-76-dependent signals at different stages of T cell development.
J.
Yoder, C.
Pham, Y.
-M.
Iizuka, O.
Kanagawa, S.
K.
Liu, J.
McGlade, A.
M.
Cheng, Requirement for the SLP-76 adaptor GADS in T cell development.
Science
291
, 1987-1991 (2001).
[Abstract]
[Full Text].
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