Aquagenic Wrinkling of Palms: Section A Case Report

Aquagenic wrinkling of the palms is a rare skin condition characterised by rapid wrinkling of the palms after water exposure, occurring within 2-4 minutes, compared to the normal physiological response which takes about 11 minutes. This condition predominantly affects young adult females and involves the eccrine secretory coil and acrosyringium. Cystic fibrosis-associated forms, drug-induced cases, and idiopathic forms have been described. Initial assessment of aquagenic wrinkling of the palms can be performed in a primary care setting. A comprehensive medical history and physical examination should be conducted, with additional investigations as required based on the patient’s presentation. The present case report presents a case of a 23-year-old male with aquagenic wrinkling of the palms, demonstrating wrinkling of the skin within two minutes of water immersion without any underlying systemic condition or drug-induced factors.